Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.47 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553284 | 0.90 | ROCK2 (0.50) | ROCK2ROCK1 | |
| SCHEMBL4552782 | 0.87 | ROCK2 (0.51) | NAMPTROCK2ROCK1 | |
| SCHEMBL4882767 | 0.85 | ROCK2 (0.56) | ROCK2ROCK1 | |
| SCHEMBL14425153 | 0.84 | SMYD3 (0.49) | ROCK2ROCK1BRD4 | |
| SCHEMBL11898543 | 0.78 | HPGDS (0.48) | EGLN1NAMPTROCK2ROCK1BRD4 | |
| SCHEMBL15389532 | 0.76 | NAMPT (0.62) | NAMPTROCK2ATRBRD4NPC1 | |
| SCHEMBL5525010 | 0.76 | ACACB (0.48) | ROCK2ROCK1 | |
| SCHEMBL5525008 | 0.76 | ACACB (0.48) | ROCK2ROCK1 | |
| SCHEMBL5077141 | 0.75 | THRB (0.56) | EGLN1NAMPTROCK2NPC1RAB9A | |
| SCHEMBL5412609 | 0.75 | MAOB (0.55) | EGLN1NAMPTMAPK1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |