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Sugi Predict / Compounds / SCHEMBL1337355

SCHEMBL1337355

SCHEMBL1337355

Cn1c(=O)c(-c2ccc(Cl)cc2Cl)cc2c3cc(C(=O)CC(=O)C(=O)O)ccc3n(C)c21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ERCC5 P28715 5/20 0.41
▸ FEN1 P39748 5/20 0.41
▸ HAO1 Q9UJM8 1/20 0.35
▸ CNR1 P21554 4/20 0.34
▸ CNR2 P34972 4/20 0.34
▸ GABRA1 P14867 3/20 0.34
▸ GABRG2 P18507 2/20 0.34
▸ GABRB3 P28472 2/20 0.34
▸ GABRA5 P31644 2/20 0.34
▸ CXCR3 P49682 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ HSD17B10 Q99714 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ HDAC1 Q13547 1/20 0.34
▸ HDAC8 Q9BY41 1/20 0.34
▸ HDAC6 Q9UBN7 1/20 0.34
▸ EGFR P00533 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1337154 0.90 CNR1 (0.37) CNR1CNR2GABRA1GABRG2GABRB3
SCHEMBL1337139 0.88 LMNA (0.40) CNR1CNR2GABRA1GABRG2GABRB3
SCHEMBL1336619 0.88 GABRA1 (0.38) CNR1CNR2GABRA1GABRG2GABRB3
SCHEMBL1338314 0.88 GSK3B (0.37) CNR1CNR2GABRA1GABRG2GABRB3
SCHEMBL1339851 0.87 CNR1 (0.37) CNR1CNR2GABRA1GABRG2GABRB3
SCHEMBL1337009 0.87 GSK3B (0.38) CNR1CNR2GABRA1GABRG2GABRB3
SCHEMBL1339573 0.87 KDM4E (0.46) CNR1CNR2GABRA1GABRG2GABRB3
Hydrochloric Acid SCHEMBL1338472 0.86 CNR1 (0.36) CNR1CNR2GABRA1GABRG2GABRB3
SCHEMBL1339222 0.86 CNR1 (0.35) CNR1CNR2GABRA1GABRG2GABRB3
SCHEMBL3577537 0.85 MAPT (0.39) CNR1CNR2GABRA1GABRG2GABRB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8063061-B2 6-(2-amino-1,3-thiazol-4-yl)-3-(2,4-dichlorophenyl)-1-methyl-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one; affinity for GABAA-receptor-associated omega modulatory sites SANOFI-AVENTIS (FR) 2011-11-22 — — US disclosed
EP-1940840-B1 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF SANOFI AVENTIS (FR) 2010-07-21 — — EP disclosed
US-20080262020-A1 6-Heteroarylpyridoindolone Derivatives, Their Preparation and Therapeutic Use Thereof SANOFI-AVENTIS (FR) 2008-10-23 — — US disclosed
EP-1940840-A1 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF Sanofi-Aventis (FR) 2008-07-09 — — EP disclosed
WO-2007045758-A1 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF SANOFI AVENTIS (FR) 2007-04-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080262020-A1 6-Heteroarylpyridoindolone Derivatives, Their Preparation and Therapeutic Use Thereof CYP11B2, CYP11B1, CYP2D6 ERCC5 2737/4885FEN1 3314/4885HAO1 3799/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.