Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PLEC | Q15149 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13374001 | 0.85 | MAPT (0.43) | NPC1RAB9AMAPTPOLBALDH1A1 | |
| SCHEMBL13373996 | 0.79 | DHFR (0.35) | NPC1RAB9AMAPTALDH1A1MEN1 | |
| SCHEMBL9806039 | 0.78 | MAPT (0.43) | NPC1RAB9AMAPTTDP1L3MBTL1 | |
| SCHEMBL10777343 | 0.75 | TDP1 (0.55) | NPC1RAB9AMAPTTDP1RORC | |
| SCHEMBL5953095 | 0.74 | TDP1 (0.70) | RAB9AMAPTTDP1RORCALDH1A1 | |
| SCHEMBL5952401 | 0.72 | MAPT (0.59) | NPC1RAB9AMAPTTDP1L3MBTL1 | |
| SCHEMBL10134070 | 0.71 | ALDH1A1 (0.44) | MAPTTDP1L3MBTL1RORCNPSR1 | |
| SCHEMBL9886101 | 0.70 | MAPT (0.60) | NPC1RAB9AMAPTTDP1L3MBTL1 | |
| SCHEMBL326803 | 0.70 | NQO1 (0.52) | MAPTTDP1L3MBTL1NPSR1MTNR1A | |
| SCHEMBL10778087 | 0.69 | KDM4E (0.54) | NPC1RAB9AMAPTTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |