Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.67 |
| ▸ | PARP1 | P09874 | 1/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.67 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.63 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.62 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.62 |
| ▸ | BLK | P51451 | 1/20 | 0.60 |
| ▸ | BTK | Q06187 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.58 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.58 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.58 |
| ▸ | DDX3X | O00571 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL394748 | 0.90 | KCNK3 (0.76) | PTGS1KCNK3KCNK9DDX3XSMN1; SMN2 | |
| SCHEMBL29568808 | 0.90 | PTGS1 (0.79) | PTGS1KCNK3KCNK9DDX3XSMN1; SMN2 | |
| SCHEMBL8399784 | 0.90 | PTGS1 (0.79) | PTGS1KCNK3KCNK9DDX3XSMN1; SMN2 | |
| SCHEMBL24628407 | 0.89 | PTGS1 (0.65) | PTPN1PARP1PTGS1TRPV1KCNK3 | |
| SCHEMBL29672230 | 0.87 | PTGS1 (0.74) | PTGS1KCNK3KCNK9DDX3XSMN1; SMN2 | |
| SCHEMBL927121 | 0.87 | PTGS1 (0.74) | PTGS1KCNK3KCNK9DDX3XSMN1; SMN2 | |
| SCHEMBL6348320 | 0.86 | PARP1 (0.65) | PTPN1PARP1TRPV1KCNK3KCNK9 | |
| SCHEMBL21295922 | 0.84 | PTGS1 (0.70) | PTGS1KCNK3KCNK9DDX3XSMN1; SMN2 | |
| SCHEMBL26737633 | 0.83 | DDX3X (0.69) | PTGS1KCNK3KCNK9BTKDDX3X | |
| SCHEMBL10090679 | 0.83 | PARP1 (0.74) | PTPN1PARP1TRPV1KCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291352-B1 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | CENTRE NAT RECH SCIENT (FR) | 2017-09-13 | — | — | EP | disclosed |
| US-9073835-B2 | N-acylthiourea and N-acylurea inhibitors of the Hedgehog protein signalling pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-07-07 | — | — | US | disclosed |
| US-20110275663-A1 | N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275663-A1 | N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway | SHH, GLI1, SMO | PTPN1 2381/4885PARP1 4642/4885PTGS1 2760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.