Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4487412 | 0.97 | MAPT (0.42) | MAPTKDM4EALOX15MEN1KMT2A | |
| SCHEMBL4431629 | 0.82 | ALOX5 (0.50) | MAPTKDM4EALOX15MEN1KMT2A | |
| SCHEMBL4431627 | 0.82 | ALOX5 (0.50) | MAPTKDM4EALOX15MEN1KMT2A | |
| SCHEMBL10137636 | 0.82 | ALOX5 (0.50) | MAPTKDM4EALOX15MEN1KMT2A | |
| SCHEMBL13712262 | 0.80 | SLC26A6 (0.42) | MAPTKDM4EALOX15MEN1KMT2A | |
| SCHEMBL8120086 | 0.80 | ALDH1A1 (0.49) | MAPTKDM4EALOX15MEN1KMT2A | |
| SCHEMBL5657293 | 0.80 | ALDH1A1 (0.44) | MAPTKDM4EALOX15MEN1KMT2A | |
| SCHEMBL234027 | 0.80 | KDM4E (0.55) | MAPTKDM4EALOX15MEN1KMT2A | |
| SCHEMBL4495971 | 0.79 | MAPT (0.44) | MAPTKDM4EALOX15MEN1KMT2A | |
| SCHEMBL5657803 | 0.79 | ALDH1A1 (0.43) | MAPTKDM4EALOX15MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288565-B2 | Process for the synthesis of (2S,3AR,7AS)-octahydro-1H-indole carboxylic acid as an intermediate for trandolapril | ABBOTT LABORATORIES (US) | 2012-10-16 | — | — | US | disclosed |