SCHEMBL13376552

SCHEMBL13376552

C[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CC[C@@H]2N

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 9/20 0.68
GLUL P15104 2/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14115979 1.00 NR3C1 (0.68) NR3C1GLUL
SCHEMBL13376688 1.00 NR3C1 (0.68) NR3C1GLUL
SCHEMBL14091710 0.93 NR3C1 (0.71) NR3C1GLUL
SCHEMBL13376622 0.90 NR3C1 (0.55) NR3C1GLUL
SCHEMBL13376610 0.90 NR3C1 (0.55) NR3C1GLUL
SCHEMBL14091722 0.88 NR3C1 (0.67) NR3C1GLUL
SCHEMBL14091724 0.88 NR3C1 (0.67) NR3C1GLUL
SCHEMBL12023015 0.86 NR3C1 (0.71) NR3C1GLUL
SCHEMBL2618327 0.84 NR3C1 (0.64) NR3C1GLUL
SCHEMBL2631126 0.84 NR3C1 (0.64) NR3C1GLUL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599201-B1 SELECTIVE NON-STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS MERCK SHARP & DOHME (US) 2010-04-14 EP disclosed
US-7411073-B2 Selective non-steroidal glucocorticoid receptor modulators MERCK & CO., INC. (US) 2008-08-12 US disclosed
US-7411073-B2 Selective non-steroidal glucocorticoid receptor modulators MERCK & CO., INC. (US) 2008-08-12 US disclosed