SCHEMBL1337848

SCHEMBL1337848

O=C(O)C1=CC=C(c2ccc(C(=O)O)cc2)C(C(F)(F)F)(C(F)(F)F)C1

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 1/20 0.42
BAD Q92934 1/20 0.42
RXRA P19793 4/20 0.40
RXRB P28702 4/20 0.40
RXRG P48443 2/20 0.40
PDK2 Q15119 4/20 0.37
SRD5A2 P31213 1/20 0.36
HDAC1 Q13547 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
TP53 P04637 1/20 0.35
TSHR P16473 1/20 0.35
TTR P02766 1/20 0.35
CYP2C8 P10632 1/20 0.35
RARA P10276 1/20 0.34
RARB P10826 1/20 0.34
RARG P13631 1/20 0.34
KDM4E B2RXH2 1/20 0.33
LMNA P02545 1/20 0.33
HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30359384 0.71 RXRA (0.40) BCL2L1BADRXRARXRBRXRG
SCHEMBL28148964 0.66 BCL2L1 (0.40) BCL2L1BADRARARARBRARG
SCHEMBL14018385 0.62 TSHR (0.80) BCL2L1BADRXRARXRBRXRG
Terephthalic Acid SCHEMBL9577834 0.62 TSHR (0.80) BCL2L1BADRXRARXRBRXRG
SCHEMBL2637326 0.62 TSHR (0.80) BCL2L1BADRXRARXRBRXRG
SCHEMBL69873 0.62 TSHR (0.80) BCL2L1BADRXRARXRBRXRG
Terephthalic Acid SCHEMBL6664201 0.62 TSHR (0.92) BCL2L1BADSRD5A2TP53TSHR
SCHEMBL202110 0.61 BCL2L1 (1.00) BCL2L1BADRXRARXRBRXRG
SCHEMBL505133 0.61 SRD5A2 (0.77) BCL2L1BADRXRARXRBRXRG
Terephthalic Acid SCHEMBL23302228 0.61 TSHR (0.67) BCL2L1BADRXRARXRBRXRG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2131247-B1 Toner kit, image formation method and image forming apparatus RICOH CO LTD (JP) 2016-09-28 EP disclosed
US-8062821-B2 Toner, and process cartridge and image forming apparatus using the same RICOH COMPANY, LIMITED (JP) 2011-11-22 US disclosed
EP-2131247-A1 Toner kit, image formation method and image forming apparatus Ricoh Company, Limited (JP) 2009-12-09 EP disclosed
US-20090232542-A1 TONER, AND PROCESS CARTRIDGE AND IMAGE FORMING APPARATUS USING THE SAME RICOH COMPANY LIMITED (JP) 2009-09-17 US disclosed
US-7416822-B2 Resin and resin composition ASAHI KASEI EMD CORPORATION (JP) 2008-08-26 US disclosed
US-20080176159-A1 TONER, PROCESS CARTRIDGE AND IMAGE FORMING APPARATUS RICOH COMPANY LIMITED (JP) 2008-07-24 US disclosed
US-20070154843-A1 Resin and resin composition ASAHI KASEI EMD CORPORATION (JP) 2007-07-05 US disclosed
EP-1707588-A1 RESIN AND RESIN COMPOSITION Asahi Kasei EMD Corporation (JP) 2006-10-04 EP disclosed