Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 20/20 | 0.66 |
| ▸ | HTR1A | P08908 | 3/20 | 0.66 |
| ▸ | HTR1D | P28221 | 2/20 | 0.66 |
| ▸ | HTR1B | P28222 | 2/20 | 0.66 |
| ▸ | HTR1F | P30939 | 2/20 | 0.66 |
| ▸ | HTR7 | P34969 | 2/20 | 0.66 |
| ▸ | DRD3 | P35462 | 2/20 | 0.66 |
| ▸ | DRD2 | P14416 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029770 | 0.86 | HTR6 (0.72) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| Trifluoroacetic Acid SCHEMBL4021334 | 0.82 | HTR6 (0.58) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3622368 | 0.82 | HTR6 (0.67) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL4023837 | 0.82 | HTR6 (0.76) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3624652 | 0.82 | HTR6 (0.71) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL16796502 | 0.82 | HTR6 (0.71) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL7449413 | 0.82 | HTR6 (0.71) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3611374 | 0.82 | HTR6 (0.80) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3622409 | 0.81 | HTR6 (0.77) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL1692232 | 0.81 | HTR6 (0.66) | HTR6HTR1AHTR1DHTR1BHTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696192-B2 | Tricyclic anilide spirolactam CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-04-13 | — | — | US | disclosed |
| US-20080214511-A1 | Tricyclic Anilide Spirolactam Cgrp Receptor Antagonists | MERCK & CO., INC. (US) | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214511-A1 | Tricyclic Anilide Spirolactam Cgrp Receptor Antagonists | BDKRB1, CALCRL, BDKRB2 | HTR6 231/4885HTR1A 164/4885HTR1D 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.