Sugi Predict

Sugi Predict / Compounds / SCHEMBL1338679

SCHEMBL1338679

SCHEMBL1338679

O=C(OCc1ccccc1)N1CCOCC1F

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.59
▸ KMT2A Q03164 1/20 0.59
▸ NPSR1 Q6W5P4 1/20 0.59
▸ TMEM97 Q5BJF2 3/20 0.51
▸ SIGMAR1 Q99720 3/20 0.51
▸ PREP P48147 1/20 0.48
▸ SMN1; SMN2 Q16637 2/20 0.48
▸ NPC1 O15118 2/20 0.48
▸ RAB9A P51151 2/20 0.48
▸ KLK7 P49862 2/20 0.47
▸ KLK5 Q9Y337 1/20 0.47
▸ CYP2C19 P33261 1/20 0.46
▸ PSEN1 P49768 1/20 0.45
▸ PSEN2 P49810 1/20 0.45
▸ APH1B Q8WW43 1/20 0.45
▸ NCSTN Q92542 1/20 0.45
▸ APH1A Q96BI3 1/20 0.45
▸ PSENEN Q9NZ42 1/20 0.45
▸ PDK1 Q15118 1/20 0.44
▸ PDK2 Q15119 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31552252 0.85 MEN1 (0.54) MEN1KMT2ANPSR1TMEM97SIGMAR1
SCHEMBL31552166 0.85 MEN1 (0.54) MEN1KMT2ANPSR1TMEM97SIGMAR1
SCHEMBL14636885 0.84 MEN1 (0.59) MEN1KMT2ANPSR1TMEM97SIGMAR1
SCHEMBL31536535 0.84 MEN1 (0.59) MEN1KMT2ANPSR1TMEM97SIGMAR1
SCHEMBL29129700 0.84 MEN1 (0.59) MEN1KMT2ANPSR1TMEM97SIGMAR1
SCHEMBL29129699 0.84 MEN1 (0.59) MEN1KMT2ANPSR1TMEM97SIGMAR1
SCHEMBL2072827 0.84 MEN1 (0.59) MEN1KMT2ANPSR1TMEM97SIGMAR1
SCHEMBL12819576 0.84 MEN1 (0.59) MEN1KMT2ANPSR1TMEM97SIGMAR1
SCHEMBL14646652 0.83 MEN1 (0.58) MEN1KMT2ANPSR1TMEM97SIGMAR1
SCHEMBL30254204 0.83 MEN1 (0.58) MEN1KMT2ANPSR1TMEM97SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107540625-B Preparation method of linezolid 正大天晴药业集团股份有限公司 2021-06-25 — — CN disclosed
US-9586913-B2 Processes for the preparation of linezolid using novel intermediates SYMED LABS LIMITED (IN) 2017-03-07 — — US disclosed
US-20160102064-A1 IMPROVED PROCESSES FOR THE PREPARATION OF LINEZOLID USING NOVEL INTERMEDIATES SYMED LABS LIMITED (IN) 2016-04-14 — — US disclosed
EP-2989097-A1 IMPROVED PROCESSES FOR THE PREPARATION OF LINEZOLID USING NOVEL INTERMEDIATES Symed Labs Limited (IN) 2016-03-02 — — EP disclosed
WO-2015068121-A1 PROCESS FOR PREPARATION OF CRYSTALLINE FORM I OF LINEZOLID AND ITS COMPOSITIONS UNIMARK REMEDIES LTD. (IN) 2015-05-14 — — WO disclosed
WO-2014174522-A1 IMPROVED PROCESSES FOR THE PREPARATION OF LINEZOLID USING NOVEL INTERMEDIATES SYMED LABS LIMITED (IN) 2014-10-30 — — WO disclosed
WO-2014045292-A1 IMPROVED PROCESS FOR THE PREPARATION OF LINEZOLID INTERMEDIATE SYMED LABS LIMITED (IN) 2014-03-27 — — WO disclosed
US-8658789-B2 Method for preparing linezolid and intermediates thereof LIANHE CHEMICAL TECHNOLOGY CO., LTD. (CN) 2014-02-25 — — US disclosed
EP-2388251-B1 METHOD FOR PREPARING LINEZOLID AND INTERMEDIATES THEREOF LIANHE CHEMICAL TECHNOLOGY CO LTD (CN) 2013-08-28 — — EP disclosed
US-20130137864-A1 PROCESS FOR THE PREPARATION OF LINEZOLID ALEMBIC PHARMACEUTICALS, LTD. (IN) 2013-05-30 — — US disclosed
EP-2388251-A1 METHOD FOR PREPARING LINEZOLID AND INTERMEDIATES THEREOF Lianhe Chemical Technology Co., Ltd. (CN) 2011-11-23 — — EP disclosed
US-20110275805-A1 METHOD FOR PREPARING LINEZOLID AND INTERMEDIATES THEREOF LIANHE CHEMICAL TECHNOLOGY CO., LTD. (CN) 2011-11-10 — — US disclosed
US-8038543-B2 Golf swing training device CAPESIUS DEAN C 2011-10-18 — — US disclosed
CN-101948442-A Preparation method of linezolid and preparation thereof JIAN FU 2011-01-19 — — CN disclosed
WO-2009063505-A2 PROCESS FOR PREPARATION OF (S) (N-[[3-[3-FLUORO-4-(4-MORPHOLINYL) HEN L -2-OXO-5-OXAZOLIDIN L METHYL]ACETAMIDE USV LIMITED (IN) 2009-05-22 — — WO disclosed
EP-0717738-B1 SUBSTITUTED OXAZINE AND THIAZINE OXAZOLIDINONE ANTIMICROBIALS UPJOHN CO (US) 1999-10-20 — — EP disclosed
US-5880118-A Substituted oxazine and thiazine oxazolidinone antimicrobials PHARMACIA & UPJOHN COMPANY (US) 1999-03-09 — — US disclosed
US-5688792-A BACTERICIDES PHARMACIA & UPJOHN COMPANY (US) 1997-11-18 — — US disclosed
EP-0717738-A1 SUBSTITUTED OXAZINE AND THIAZINE OXAZOLIDINONE ANTIMICROBIALS PHARMACIA & UPJOHN COMPANY (US) 1996-06-26 — — EP disclosed
WO-1995007271-A1 SUBSTITUTED OXAZINE AND THIAZINE OXAZOLIDINONE ANTIMICROBIALS THE UPJOHN COMPANY (US) 1995-03-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160102064-A1 IMPROVED PROCESSES FOR THE PREPARATION OF LINEZOLID USING NOVEL INTERMEDIATES CYP3A5, SBDS, MLYCD MEN1 3920/4885KMT2A 533/4885NPSR1 4726/4885
US-20130137864-A1 PROCESS FOR THE PREPARATION OF LINEZOLID CYP3A5, CYP2C9, CYP2C19 MEN1 1680/4885KMT2A 313/4885NPSR1 3743/4885
US-20110275805-A1 METHOD FOR PREPARING LINEZOLID AND INTERMEDIATES THEREOF HDAC9, KAT5, ACMSD MEN1 3608/4885KMT2A 158/4885NPSR1 4704/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.