⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL819464 | 0.59 | — | — | |
| SCHEMBL12827845 | 0.57 | ALOX15 (0.41) | — | |
| SCHEMBL12361763 | 0.57 | ALOX15 (0.41) | — | |
| SCHEMBL12874856 | 0.57 | ALOX15 (0.41) | — | |
| SCHEMBL8382035 | 0.57 | — | — | |
| SCHEMBL819349 | 0.57 | ALOX15 (0.41) | — | |
| SCHEMBL17808767 | 0.55 | — | — | |
| SCHEMBL6634482 | 0.55 | ALDH1A1 (0.32) | — | |
| SCHEMBL24514891 | 0.50 | — | — | |
| SCHEMBL60145 | 0.48 | TTR (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-58146543-A | — | — | None | — | — | JP | disclosed |
| US-8063212-B2 | Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer | ELI LILLY AND COMPANY (US) | 2011-11-22 | — | — | US | disclosed |
| EP-2125794-B1 | IMIDAZOLIDINONYL AMINOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2010-10-20 | — | — | EP | disclosed |
| US-20100081641-A1 | IMIDAZOLIDINONYL AMINOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER | ELI LILLY AND COMPANY | 2010-04-01 | — | — | US | disclosed |
| EP-2125794-A1 | IMIDAZOLIDINONYL AMINOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER | Eli Lilly & Company (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008076705-A1 | IMIDAZOLIDINONYL AMINOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER | ELI LILLY AND COMPANY (US) | 2008-06-26 | — | — | WO | disclosed |
| EP-0087963-B1 | PHTHALONITRILE DERIVATIVES AND LIQUID CRYSTAL COMPOSITIONS CONTAINING THEM | Hitachi, Ltd. (JP) | 1989-05-03 | — | — | EP | disclosed |
| US-4479885-A | Phthalonitrile derivatives and a liquid crystal composition containing the same | HITACHI, LTD. (JP) | 1984-10-30 | — | — | US | disclosed |
| EP-0087963-A2 | Phthalonitrile derivatives and liquid crystal compositions containing them | Hitachi, Ltd. (JP) | 1983-09-07 | — | — | EP | disclosed |
| JP-S58146543-A | PREPARATION OF PHTHALONITRILE DERIVATIVE | MITSUBISHI CHEM IND LTD | 1983-09-01 | — | — | JP | disclosed |