Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 7/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 7/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3534758 | 0.77 | ALDH1A1 (0.49) | ALDH1A1CYP1A2CYP2C19CYP2D6HPGD | |
| SCHEMBL13082597 | 0.76 | TSHR (0.63) | ALDH1A1CYP1A2CYP2C19ALOX15KMT2A | |
| SCHEMBL13403265 | 0.75 | MKNK1 (0.49) | ALDH1A1KMT2AMEN1RAB9AMAPT | |
| SCHEMBL3538145 | 0.74 | RAB9A (0.50) | ALDH1A1CYP1A2CYP2C19CYP2D6HPGD | |
| SCHEMBL1164664 | 0.71 | ALOX15 (0.51) | ALDH1A1CYP1A2CYP2C19ALOX15RAB9A | |
| SCHEMBL13403261 | 0.71 | TTR (0.45) | ALDH1A1HPGDALOX15KMT2AMEN1 | |
| SCHEMBL11577171 | 0.70 | CYP1A2 (0.70) | ALDH1A1CYP1A2CYP2C19CYP2D6HPGD | |
| SCHEMBL195793 | 0.69 | ALDH1A1 (0.56) | ALDH1A1CYP1A2CYP2C19ALOX15KMT2A | |
| SCHEMBL701782 | 0.69 | CA12 (0.71) | ALDH1A1CYP1A2CYP2C19ALOX15RAB9A | |
| SCHEMBL31003218 | 0.69 | ALDH1A1 (0.56) | ALDH1A1CYP1A2CYP2C19ALOX15KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7700602-B2 | Amino-5,5-diphenylimidazolone derivatives for the inhibition of β-secretase | WYETH LLC (US) | 2010-04-20 | — | — | US | disclosed |
| US-20090093498-A1 | AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE | WYETH (US) | 2009-04-09 | — | — | US | disclosed |
| US-7482349-B2 | Amino-5,5-diphenylimidazolone derivatives for the inhibition of β-secretase | WYETH (US) | 2009-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093498-A1 | AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE | BACE1, BACE2, APP | ALDH1A1 2182/4885CYP1A2 2517/4885CYP2C19 3238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.