Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10068738 | 0.83 | HCRTR1 (0.38) | HTTLMNAHCRTR2HCRTR1ALDH1A1 | |
| SCHEMBL4424169 | 0.81 | ALDH1A1 (0.49) | HTTMEN1KMT2ARAB9ALMNA | |
| SCHEMBL4412254 | 0.79 | L3MBTL1 (0.49) | HTTMEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL13403434 | 0.79 | ALDH1A1 (0.43) | HTTMEN1KMT2ARAB9ALMNA | |
| SCHEMBL4410194 | 0.78 | L3MBTL1 (0.44) | MEN1KMT2ARAB9ALMNAL3MBTL1 | |
| SCHEMBL4421352 | 0.77 | ALDH1A1 (0.39) | MEN1KMT2ARAB9ALMNANPC1 | |
| SCHEMBL9022798 | 0.76 | ALDH1A1 (0.53) | HTTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL2173133 | 0.72 | HCAR3 (0.35) | HTTRAB9ALMNANPC1L3MBTL1 | |
| SCHEMBL3553789 | 0.72 | POLB (0.43) | MEN1KMT2ARAB9ALMNANPC1 | |
| SCHEMBL13437729 | 0.71 | KMT2A (0.40) | HTTMEN1KMT2ARAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696203-B2 | DNA-PK inhibitors | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-04-13 | — | — | US | disclosed |
| US-7696203-B2 | DNA-PK inhibitors | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-04-13 | — | — | US | disclosed |