Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | TP53 | P04637 | 8/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | QPCT | Q16769 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3280331 | 0.88 | TP53 (0.53) | MAPTTP53L3MBTL1SCN9AACHE | |
| SCHEMBL13407675 | 0.78 | MAPT (0.46) | MAPTTP53L3MBTL1SCN9AACHE | |
| SCHEMBL3029407 | 0.72 | MAPT (0.50) | MAPTTP53L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL3029406 | 0.72 | MAPT (0.50) | MAPTTP53L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL13407483 | 0.72 | MDM2 (0.51) | TP53L3MBTL1SCN9AACHESCN5A | |
| SCHEMBL3956190 | 0.67 | SCN9A (0.62) | MAPTSCN9ASCN5AKCNQ2KCNA5 | |
| SCHEMBL22781472 | 0.67 | GAA (0.55) | MAPTTP53L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL13568323 | 0.66 | HSD17B10 (0.55) | SCN9ASCN5AALDH1A1KCNQ2KCNA5 | |
| SCHEMBL18569320 | 0.66 | GAA (0.56) | L3MBTL1ALDH1A1KDM4EHPGDGAA | |
| SCHEMBL17366160 | 0.66 | ALDH1A1 (0.49) | MAPTTP53SCN9ASCN5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7705021-B2 | Isoindolone compounds, compositions containing the same, and methods of use thereof for the treatment of viral infections related to the etiology of cancer | FOX CHASE CANCER CENTER (US) | 2010-04-27 | — | — | US | disclosed |