Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | QPCT | Q16769 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | FPR1 | P21462 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3029407 | 1.00 | MAPT (0.50) | MAPTHSD17B10GAANPSR1RAB9A | |
| SCHEMBL13407482 | 0.72 | MAPT (0.51) | MAPTGAATP53QPCTALDH1A1 | |
| SCHEMBL9893329 | 0.72 | TOP1 (0.52) | GAAALDH1A1HTTALOX15KDM4E | |
| SCHEMBL9893246 | 0.69 | MEN1 (0.45) | MAPTHSD17B10ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL18568866 | 0.67 | GAA (0.68) | MAPTGAAALDH1A1KDM4EKMT2A | |
| SCHEMBL12732961 | 0.65 | QPCT (0.61) | MAPTHSD17B10GAANPSR1RAB9A | |
| SCHEMBL12732963 | 0.65 | QPCT (0.61) | MAPTHSD17B10GAANPSR1RAB9A | |
| SCHEMBL17366180 | 0.65 | GAA (0.55) | MAPTGAANPSR1ALDH1A1HTT | |
| SCHEMBL22781472 | 0.65 | GAA (0.55) | MAPTGAARAB9ATP53ALDH1A1 | |
| SCHEMBL8273178 | 0.65 | GAA (0.55) | MAPTGAATP53ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216843-A1 | NOVEL SALT 628 | ASTRAZENECA R&D | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216843-A1 | NOVEL SALT 628 | REN, SCN8A, SLC38A7 | MAPT 494/4885HSD17B10 3129/4885GAA 1926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.