Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | TGM2 | P21980 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13407756 | 0.82 | MEN1 (0.64) | ALDH1A1KMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL13407758 | 0.82 | ALDH1A1 (0.68) | ALDH1A1KMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL13407754 | 0.79 | KDM4E (0.70) | ALDH1A1KMT2AMEN1NPSR1TP53 | |
| SCHEMBL20228946 | 0.79 | ALDH1A1 (0.64) | ALDH1A1KMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL20228922 | 0.77 | ALDH1A1 (0.72) | ALDH1A1KMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL20228945 | 0.76 | KMT2A (0.60) | ALDH1A1KMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL12136764 | 0.74 | MEN1 (0.70) | ALDH1A1KMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL21528229 | 0.74 | ALDH1A1 (0.67) | ALDH1A1KMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL13407750 | 0.73 | MAPT (0.75) | ALDH1A1KMT2AMEN1LMNANPSR1 | |
| SCHEMBL20228944 | 0.73 | ALDH1A1 (1.00) | ALDH1A1KMT2AMEN1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140024662-A1 | COMPOUNDS, SCREENS, AND METHODS OF TREATMENT | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2014-01-23 | — | — | US | disclosed |
| US-20100087453-A1 | COMPOUNDS, SCREENS, AND METHODS OF TREATMENT | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140024662-A1 | COMPOUNDS, SCREENS, AND METHODS OF TREATMENT | ASAH2, LITAF, CYP27A1 | ALDH1A1 1140/4885KMT2A 4813/4885MEN1 2053/4885 |
| US-20100087453-A1 | COMPOUNDS, SCREENS, AND METHODS OF TREATMENT | ASAH2, LITAF, CYP27A1 | ALDH1A1 1121/4885KMT2A 4822/4885MEN1 2131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.