Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18464205 | 0.80 | NR1H4 (0.58) | CNR2CNR1NR1H4SMN1; SMN2 | |
| SCHEMBL7141111 | 0.78 | HTT (0.63) | CNR2CNR1MEN1KMT2ANR1H4 | |
| SCHEMBL5085615 | 0.73 | CNR2 (0.53) | CNR2CNR1RAB9A | |
| SCHEMBL6844891 | 0.72 | LOXL2 (0.50) | MEN1KMT2AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL11900371 | 0.72 | SRD5A2 (0.57) | MEN1KMT2ARAB9AALDH1A1NPC1 | |
| SCHEMBL2938750 | 0.72 | MLYCD (0.60) | CNR2CNR1SMN1; SMN2 | |
| SCHEMBL65794 | 0.72 | MAPT (0.61) | MEN1KMT2AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL4838149 | 0.71 | NOTUM (0.49) | ALDH1A1NPC1SMN1; SMN2HTTKDM4E | |
| SCHEMBL15955652 | 0.71 | ALDH1A1 (0.52) | NR1H4HSP90AA1ALDH1A1SMN1; SMN2EPHX2 | |
| SCHEMBL22073484 | 0.70 | NR1H4 (0.48) | CNR2CNR1MEN1KMT2ANR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063081-B2 | N-(2-Phenoxyphenyl)-N'-(thiazol-2-yl)urea; glucokinase inhibitor; antidiabetic, hypoglycemic agent; activators of glucokinase | NOVO NORDISK A/S (DK) | 2011-11-22 | — | — | US | disclosed |
| US-7897628-B2 | {2-[3-(4-Methyl-2-[2-methypropoxy]phenyl)-ureido]-thiazol-4-yl}-acetic acid ethyl ester; glucokinase inhibitor; antidiabetic, hypoglycemic agent; activators of glucokinase | NOVO NORDISK A/S (DK) | 2011-03-01 | — | — | US | disclosed |