Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.75 |
| ▸ | HTT | P42858 | 2/20 | 0.75 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.57 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.57 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.57 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ELANE | P08246 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL392493 | 0.95 | MAPT (0.84) | MAPTALDH1A1HTTATMSMN1; SMN2 | |
| SCHEMBL2894531 | 0.91 | MAPT (0.72) | MAPTALDH1A1HTTATMSMN1; SMN2 | |
| SCHEMBL13412239 | 0.91 | MAPT (0.83) | MAPTALDH1A1HTTATMSMN1; SMN2 | |
| SCHEMBL8344218 | 0.91 | MAPT (0.69) | MAPTALDH1A1HTTATMSMN1; SMN2 | |
| SCHEMBL13412241 | 0.91 | MAPT (0.69) | MAPTALDH1A1HTTATMSMN1; SMN2 | |
| SCHEMBL2892089 | 0.82 | ELANE (0.74) | MAPTALDH1A1HTTSMN1; SMN2ELANE | |
| SCHEMBL4547759 | 0.82 | ALDH1A1 (0.61) | MAPTALDH1A1HTTATMSMN1; SMN2 | |
| SCHEMBL14899931 | 0.82 | MAPT (0.70) | MAPTALDH1A1HTTATMSMN1; SMN2 | |
| SCHEMBL3394058 | 0.79 | ALDH1A1 (0.71) | MAPTALDH1A1HTTSMN1; SMN2GAA | |
| SCHEMBL19752716 | 0.79 | ALDH1A1 (0.71) | MAPTALDH1A1HTTSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687510-B2 | Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes | BAYER HEALTHCARE AG (DE) | 2010-03-30 | — | — | US | disclosed |
| US-7687510-B2 | Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes | BAYER HEALTHCARE AG (DE) | 2010-03-30 | — | — | US | disclosed |