Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | ELANE | P08246 | 4/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CACNA1F | O60840 | 5/20 | 0.51 |
| ▸ | CACNA1D | Q01668 | 5/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 5/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2894531 | 0.92 | MAPT (0.72) | ALDH1A1KMT2AMEN1MAPTHTT | |
| SCHEMBL2892089 | 0.84 | ELANE (0.74) | ALDH1A1KMT2AMEN1MAPTHTT | |
| SCHEMBL13412240 | 0.82 | MAPT (0.82) | ALDH1A1KMT2AMEN1MAPTHTT | |
| SCHEMBL2678247 | 0.81 | ELANE (0.84) | ELANECYP2C9CYP3A4 | |
| SCHEMBL392493 | 0.80 | MAPT (0.84) | ALDH1A1KMT2AMEN1MAPTHTT | |
| SCHEMBL2679242 | 0.77 | ELANE (0.71) | ELANECYP2C9CYP3A4 | |
| SCHEMBL13412241 | 0.76 | MAPT (0.69) | ALDH1A1MAPTHTTELANECYP2C9 | |
| SCHEMBL14899944 | 0.75 | ELANE (0.59) | ELANE | |
| SCHEMBL8050837 | 0.74 | ELANE (0.79) | ALDH1A1MAPTLMNAELANECYP2C9 | |
| SCHEMBL2887923 | 0.74 | ELANE (0.79) | ALDH1A1MAPTLMNAELANECYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173665-B2 | I-pheny 1-3,4-dihydropyrimidin-2(1H)-one derivatives and their use | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-05-08 | — | — | US | disclosed |
| US-20100022537-A1 | I-PHENY 1-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVES AND THEIR USE | BAYER HEALTHCARE AG (DE) | 2010-01-28 | — | — | US | disclosed |
| US-7566723-B2 | 1-phenyl1-3,4-dihydropyrimidin-2(1H)-one derivatives and their use | BAYER HEALTHCARE AG (DE) | 2009-07-28 | — | — | US | disclosed |
| US-7566723-B2 | 1-phenyl1-3,4-dihydropyrimidin-2(1H)-one derivatives and their use | BAYER HEALTHCARE AG (DE) | 2009-07-28 | — | — | US | disclosed |
| WO-2004024701-A1 | HETEROCYCLIC DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022537-A1 | I-PHENY 1-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVES AND THEIR USE | TNNI3, HIF1AN, TNNT2 | ALDH1A1 742/4885KMT2A 3620/4885MEN1 3280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.