Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13412479 | 0.86 | HSD17B10 (0.50) | ALDH1A1RAB9AGABRA5GABRB2HSD17B10 | |
| SCHEMBL14206861 | 0.83 | SLC6A3 (0.45) | ALDH1A1RAB9AL3MBTL1GABRA5GABRB2 | |
| SCHEMBL13412481 | 0.80 | SMN1; SMN2 (0.56) | ALDH1A1MEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL13447427 | 0.80 | SLC6A3 (0.47) | ALDH1A1RAB9AL3MBTL1GABRA5GABRB2 | |
| SCHEMBL13412476 | 0.79 | HDAC1 (0.33) | HDAC1HDAC6 | |
| SCHEMBL13412484 | 0.78 | DPP4 (0.40) | ALDH1A1RAB9AL3MBTL1MEN1HDAC1 | |
| SCHEMBL13412478 | 0.78 | HDAC1 (0.35) | HDAC1HDAC6 | |
| SCHEMBL15581589 | 0.77 | GABRA5 (0.44) | ALDH1A1RAB9AL3MBTL1GABRA5GABRB2 | |
| SCHEMBL13412485 | 0.74 | CDK5 (0.34) | HDAC1HDAC6 | |
| SCHEMBL13412495 | 0.73 | ALDH1A1 (0.38) | ALDH1A1RAB9AGABRA5GABRB2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069347-A1 | HETEROCYCLYL-SUBSTITUTED ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS | MERCK SHARP & DOHME CORP. | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069347-A1 | HETEROCYCLYL-SUBSTITUTED ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS | LDLR, PCSK9, CYP46A1 | ALDH1A1 1154/4885RAB9A 294/4885L3MBTL1 2892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.