Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15743973 | 0.80 | SMN1; SMN2 (0.44) | SMN1; SMN2TSHRPOLBDPP4CYP3A4 | |
| SCHEMBL13394539 | 0.78 | LMNA (0.50) | SMN1; SMN2TSHRALDH1A1HPGDKMT2A | |
| SCHEMBL22222477 | 0.78 | LMNA (0.50) | SMN1; SMN2TSHRALDH1A1HPGDKMT2A | |
| SCHEMBL22222452 | 0.76 | SMN1; SMN2 (0.41) | SMN1; SMN2TSHRPOLBDPP4TP53 | |
| SCHEMBL13394542 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2TSHRPOLBDPP4TP53 | |
| SCHEMBL22222410 | 0.75 | SRD5A1 (0.39) | ALOX12ALDH1A1KDM4EHTTGRM2 | |
| SCHEMBL13413039 | 0.74 | PDE4A (0.46) | TSHRTP53ALDH1A1HPGDKDM1A | |
| SCHEMBL13413431 | 0.72 | HTR6 (0.49) | DPP4TP53RECQLKDM1ARCOR1 | |
| SCHEMBL13413238 | 0.69 | LMNA (0.36) | ALDH1A1KDM4EHSD17B10HTTGRM2 | |
| SCHEMBL13413565 | 0.69 | HTT (0.47) | SMN1; SMN2TSHRPOLBCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100099716-A1 | CETP INHIBITORS | MERCK SHARP & DOHME LLC | 2010-04-22 | — | — | US | disclosed |
| US-20080119476-A1 | Cetp Inhibitors | ALI AMJAD | 2008-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119476-A1 | Cetp Inhibitors | CETP, APOB, MTTP | SMN1; SMN2 4859/4885TSHR 2302/4885POLB 1365/4885 |
| US-20100099716-A1 | CETP INHIBITORS | CETP, APOB, MTTP | SMN1; SMN2 4859/4885TSHR 2302/4885POLB 1365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.