Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD5 | Q86SK9 | 5/20 | 0.50 |
| ▸ | MTTP | P55157 | 6/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.41 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13419201 | 0.96 | FAAH (0.48) | SCD5MTTPHCRTR1HCRTR2FAAH | |
| SCHEMBL13419184 | 0.92 | MTTP (0.53) | MTTPHCRTR1HCRTR2FAAH | |
| SCHEMBL13419205 | 0.91 | MTTP (0.54) | MTTPHCRTR1HCRTR2FAAHRAB9A | |
| SCHEMBL5796728 | 0.91 | MTTP (0.54) | MTTPHCRTR1HCRTR2FAAHRAB9A | |
| SCHEMBL13419468 | 0.90 | HCRTR1 (0.48) | SCD5MTTPHCRTR1HCRTR2FAAH | |
| SCHEMBL13419150 | 0.90 | MTTP (0.46) | SCD5MTTPHCRTR1HCRTR2FAAH | |
| SCHEMBL13419545 | 0.90 | MTTP (0.51) | MTTPHCRTR1HCRTR2FAAHRAB9A | |
| SCHEMBL13419084 | 0.89 | MTTP (0.49) | MTTPHCRTR1HCRTR2FAAH | |
| SCHEMBL13419310 | 0.89 | FAAH (0.46) | SCD5MTTPHCRTR1HCRTR2FAAH | |
| SCHEMBL13419451 | 0.88 | MTTP (0.47) | MTTPHCRTR1HCRTR2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |