Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | MTTP | P55157 | 6/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.47 |
| ▸ | SCD5 | Q86SK9 | 5/20 | 0.46 |
| ▸ | SCD | O00767 | 2/20 | 0.46 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.45 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1E | P28566 | 1/20 | 0.42 |
| ▸ | TSPO | P30536 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13419152 | 0.96 | SCD5 (0.50) | FAAHMTTPHCRTR1HCRTR2SCD5 | |
| SCHEMBL13419184 | 0.93 | MTTP (0.53) | FAAHMTTPHCRTR1HCRTR2UBE2M | |
| SCHEMBL13419545 | 0.92 | MTTP (0.51) | FAAHMTTPHCRTR1HCRTR2UBE2M | |
| SCHEMBL5796728 | 0.92 | MTTP (0.54) | FAAHMTTPHCRTR1HCRTR2UBE2M | |
| SCHEMBL13419205 | 0.92 | MTTP (0.54) | FAAHMTTPHCRTR1HCRTR2UBE2M | |
| SCHEMBL13419084 | 0.92 | MTTP (0.49) | FAAHMTTPHCRTR1HCRTR2UBE2M | |
| SCHEMBL13419198 | 0.91 | HCRTR1 (0.47) | FAAHMTTPHCRTR1HCRTR2 | |
| SCHEMBL13419083 | 0.90 | HTR2C (0.48) | FAAHMTTPHCRTR1HCRTR2KCNH2 | |
| SCHEMBL13419477 | 0.90 | MTTP (0.47) | FAAHMTTPHCRTR1HCRTR2UBE2M | |
| SCHEMBL13419471 | 0.90 | MTTP (0.47) | FAAHMTTPHCRTR1HCRTR2UBE2M |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |