Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 8/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | UBE2M | P61081 | 1/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.42 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.42 |
| ▸ | MICA | Q29983 | 1/20 | 0.42 |
| ▸ | RAET1L | Q5VY80 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13419205 | 1.00 | MTTP (0.54) | MTTPHCRTR1HCRTR2TSHRRECQL | |
| SCHEMBL13419184 | 0.99 | MTTP (0.53) | MTTPHCRTR1HCRTR2TSHRRECQL | |
| SCHEMBL13419463 | 0.94 | MTTP (0.49) | MTTPHCRTR1HCRTR2TSHRRECQL | |
| SCHEMBL13419451 | 0.93 | MTTP (0.47) | MTTPHCRTR1HCRTR2TSHRRECQL | |
| SCHEMBL13419201 | 0.92 | FAAH (0.48) | MTTPHCRTR1HCRTR2FAAHUBE2M | |
| SCHEMBL13419150 | 0.92 | MTTP (0.46) | MTTPHCRTR1HCRTR2TSHRRECQL | |
| SCHEMBL13419152 | 0.91 | SCD5 (0.50) | MTTPHCRTR1HCRTR2FAAHRAB9A | |
| SCHEMBL13419083 | 0.91 | HTR2C (0.48) | MTTPHCRTR1HCRTR2FAAHHTR2C | |
| SCHEMBL13419471 | 0.91 | MTTP (0.47) | MTTPHCRTR1HCRTR2FAAHUBE2M | |
| SCHEMBL13419545 | 0.91 | MTTP (0.51) | MTTPHCRTR1HCRTR2TSHRRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |
| EP-1636218-A1 | THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GmbH (DE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2005003128-A1 | THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GMBH (DE) | 2005-01-13 | — | — | WO | disclosed |