Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 10/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 4/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL149614 | 0.83 | MAOA (0.55) | PTGS2MAOAKDM4EALDH1A1CYP3A4 | |
| SCHEMBL13298866 | 0.74 | PTGS2 (0.44) | PTGS2MAOAKDM4EALDH1A1GLA | |
| SCHEMBL30865750 | 0.71 | MEN1 (0.38) | MAOAALDH1A1HPGDLMNA | |
| Xanthone SCHEMBL28434710 | 0.69 | MAOA (0.95) | MAOAKDM4EALDH1A1GLACYP3A4 | |
| SCHEMBL32667434 | 0.69 | SMN1; SMN2 (0.45) | KDM4EALDH1A1CYP3A4MAPTHPGD | |
| SCHEMBL12764548 | 0.67 | MAOA (0.61) | PTGS2MAOAKDM4EALDH1A1GLA | |
| SCHEMBL30674066 | 0.67 | MAOA (0.67) | PTGS2MAOAKDM4EALDH1A1GLA | |
| SCHEMBL12608738 | 0.67 | MAOA (0.67) | PTGS2MAOAKDM4EALDH1A1GLA | |
| Xanthone SCHEMBL41161 | 0.67 | MAOA (1.00) | PTGS2MAOAKDM4EALDH1A1GLA | |
| Xanthone SCHEMBL29358061 | 0.67 | MAOA (1.00) | PTGS2MAOAKDM4EALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501803-B2 | Garcinia derivative, its preparing method and medicinal use | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2013-08-06 | — | — | US | disclosed |
| US-8501803-B2 | Garcinia derivative, its preparing method and medicinal use | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2013-08-06 | — | — | US | disclosed |
| EP-2494971-A1 | GAMBOGIC ACID DERIVATIVES, PREPARATIVE METHODS AND USES THEREOF | China Pharmaceutical University (CN) | 2012-09-05 | — | — | EP | disclosed |
| US-20120059050-A1 | GARCINIA DERIVATIVE, ITS PREPARING METHOD AND MEDICINAL USE | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2012-03-08 | — | — | US | disclosed |
| US-20120059050-A1 | GARCINIA DERIVATIVE, ITS PREPARING METHOD AND MEDICINAL USE | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120059050-A1 | GARCINIA DERIVATIVE, ITS PREPARING METHOD AND MEDICINAL USE | GLG1, GDI1, GYPA | PTGS2 91/4885MAOA 2460/4885KDM4E 834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.