Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 7/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 3/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | PRKACG | P22612 | 1/20 | 0.31 |
| ▸ | PRKACB | P22694 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | NCF1 | P14598 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2357295 | 0.87 | CSNK2A2 (0.41) | TYK2CSNK2A2FYNMKNK1TSHR | |
| SCHEMBL13421759 | 0.87 | TYK2 (0.41) | TYK2FYNMKNK1PDE4DCCNE1 | |
| SCHEMBL13421747 | 0.84 | PRKCQ (0.41) | TYK2FYNMKNK1PDE4DTP53 | |
| SCHEMBL13421386 | 0.79 | TYK2 (0.39) | TYK2CSNK2A2FYNMKNK1PDE4D | |
| SCHEMBL13421374 | 0.78 | TYK2 (0.41) | TYK2FYNMKNK1PDE4DCCNE1 | |
| SCHEMBL13421757 | 0.76 | CSNK2A2 (0.59) | TYK2CSNK2A2PDE4DCCNE1CDK2 | |
| SCHEMBL13421753 | 0.76 | LMNA (0.39) | TYK2TSHRPDE4D | |
| SCHEMBL13422017 | 0.75 | TYK2 (0.40) | TYK2FYNMKNK1PDE4D | |
| SCHEMBL13421911 | 0.73 | FYN (0.35) | TYK2CSNK2A2FYNMKNK1PDE4D | |
| SCHEMBL3313276 | 0.73 | CSNK2A2 (0.39) | TYK2CSNK2A2FYNPDE4DPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042699-A1 | IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-15 | — | — | WO | disclosed |