Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11374067 | 0.82 | MAPT (0.38) | MAPTALDH1A1TSHRDCTPP1TDP1 | |
| SCHEMBL31135897 | 0.81 | POLB (0.36) | MAPTALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL25254093 | 0.81 | POLB (0.36) | MAPTALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL2070426 | 0.76 | MAPT (0.46) | MAPTALDH1A1MEN1KMT2AMERTK | |
| SCHEMBL15788360 | 0.75 | ALDH1A1 (0.42) | MAPTALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL321260 | 0.74 | MAPT (0.44) | MAPTALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL3102887 | 0.72 | MAPT (0.40) | MAPTALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL9121830 | 0.72 | ALDH1A1 (0.45) | MAPTALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL4627824 | 0.71 | MAPT (0.42) | MAPTALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL14853024 | 0.71 | LMNA (0.40) | ALDH1A1TSHRMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010026075-A1 | PYRIDINE DERIVATIVES AS INHIBITORS OF HIV-I REVERSE TRANSCRIPTASE | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-11 | — | — | WO | disclosed |
| US-20100056535-A1 | Inhibitors of HIV-1 reverse transcriptase | ROCHE PALO ALTO LLC | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056535-A1 | Inhibitors of HIV-1 reverse transcriptase | QTRT1, NQO2, QTRT2 | MAPT 1599/4885ALDH1A1 301/4885TSHR 3003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.