Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | STAT1 | P42224 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14607913 | 1.00 | NPC1 (0.32) | NPC1MAPTSTAT1RAB9ASMN1; SMN2 | |
| SCHEMBL3676503 | 1.00 | NPC1 (0.32) | NPC1MAPTSTAT1RAB9ASMN1; SMN2 | |
| SCHEMBL23701691 | 0.91 | LATS1 (0.31) | NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL21678184 | 0.91 | LATS1 (0.31) | NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL21678084 | 0.90 | PGK1 (0.32) | NPC1MAPTSTAT1RAB9ASMN1; SMN2 | |
| SCHEMBL23701687 | 0.90 | PGK1 (0.32) | NPC1MAPTSTAT1RAB9ASMN1; SMN2 | |
| SCHEMBL21678192 | 0.90 | NPC1 (0.31) | NPC1MAPTSTAT1RAB9ASMN1; SMN2 | |
| SCHEMBL23701685 | 0.90 | NPC1 (0.31) | NPC1MAPTSTAT1RAB9ASMN1; SMN2 | |
| SCHEMBL23701699 | 0.89 | — | — | |
| SCHEMBL21678081 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220387631-A1 | NEAR-INFRARED FLUORESCENT CONTRAST BIOIMAGING AGENTS AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-12-08 | — | — | US | disclosed |
| US-11077210-B2 | Near-infrared fluorescent contrast bioimaging agents and methods of use thereof | BETH ISRAEL DEACONESS MEDICAL CENTER (US) | 2021-08-03 | — | — | US | disclosed |
| US-11001562-B2 | Near-infrared fluorescent nerve contrast agents and methods of use thereof | BETH ISRAEL DEACONESS MEDICAL CENTER (US) | 2021-05-11 | — | — | US | disclosed |
| US-20160347727-A1 | NEAR-INFRARED FLUORESCENT NERVE CONTRAST AGENTS AND METHODS OF USE THEREOF | BETH ISRAEL DEACONESS MEDICAL CT INC (US) | 2016-12-01 | — | — | US | disclosed |
| US-20160263249-A1 | NEAR-INFRARED FLUORESCENT CONTRAST BIOIMAGING AGENTS AND METHODS OF USE THEREOF | BETH ISRAEL DEACONESS MEDICAL CENTER (US) | 2016-09-15 | — | — | US | disclosed |
| US-20160263249-A1 | NEAR-INFRARED FLUORESCENT CONTRAST BIOIMAGING AGENTS AND METHODS OF USE THEREOF | BETH ISRAEL DEACONESS MEDICAL CENTER (US) | 2016-09-15 | — | — | US | disclosed |
| US-8766238-B2 | Polymeric anions/cations | MERCK PATENT GMBH (DE) | 2014-07-01 | — | — | US | disclosed |
| US-20100059740-A1 | POLYMERIC ANIONS/CATIONS | MERCK PATENT GMBH (DE) | 2010-03-11 | — | — | US | disclosed |
| WO-2008087031-A1 | POLYMERIC ANIONS/CATIONS | MERCK PATENT GMBH (DE) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160347727-A1 | NEAR-INFRARED FLUORESCENT NERVE CONTRAST AGENTS AND METHODS OF USE THEREOF | INA, NTRK1, NGF | NPC1 713/4885MAPT 1900/4885STAT1 4467/4885 |
| US-11077210-B2 | Near-infrared fluorescent contrast bioimaging agents and methods of use thereof | CD68, MSR1, CD47 | NPC1 363/4885MAPT 3284/4885STAT1 2206/4885 |
| US-20220387631-A1 | NEAR-INFRARED FLUORESCENT CONTRAST BIOIMAGING AGENTS AND METHODS OF USE THEREOF | CD68, MSR1, CD47 | NPC1 363/4885MAPT 3284/4885STAT1 2206/4885 |
| US-20160263249-A1 | NEAR-INFRARED FLUORESCENT CONTRAST BIOIMAGING AGENTS AND METHODS OF USE THEREOF | CD68, MSR1, CD47 | NPC1 363/4885MAPT 3284/4885STAT1 2206/4885 |
| US-11001562-B2 | Near-infrared fluorescent nerve contrast agents and methods of use thereof | INA, NTRK1, NGF | NPC1 713/4885MAPT 1900/4885STAT1 4467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.