Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 5/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.33 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.33 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13429857 | 0.91 | TNNI3K (0.38) | TNNI3KEGFRMEN1KMT2ARXFP1 | |
| SCHEMBL13430248 | 0.89 | EGFR (0.42) | EGFRMEN1KMT2AHTR1AADRA1D | |
| SCHEMBL13399924 | 0.84 | AURKA (0.45) | TNNI3KEGFRMEN1KMT2ARXFP1 | |
| SCHEMBL13430250 | 0.84 | PTGS2 (0.44) | EGFRMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL13430284 | 0.77 | CCNE1 (0.32) | EGFRKDM4EGAA | |
| SCHEMBL13430208 | 0.76 | AURKA (0.37) | EGFRKMT2AKDM4EMAPTRAD52 | |
| SCHEMBL13430211 | 0.76 | AURKA (0.39) | EGFRKDM4EMAPT | |
| SCHEMBL13399940 | 0.75 | TNNI3K (0.40) | TNNI3KEGFRMEN1KMT2ARXFP1 | |
| SCHEMBL13430291 | 0.75 | AURKA (0.49) | EGFRKDM4EMAPTSTK4 | |
| SCHEMBL13430207 | 0.75 | AURKA (0.39) | EGFRSTK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036629-A2 | FUSED MULTICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2010-04-01 | — | — | WO | disclosed |