Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 3/20 | 0.34 |
| ▸ | CDK8 | P49336 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.32 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8108947 | 0.82 | GAA (0.55) | KDM4EGLAGAAPOLBCA1 | |
| SCHEMBL23682709 | 0.81 | PRKCI (0.32) | KDM4EGLAGAAKMT2A | |
| SCHEMBL8748881 | 0.81 | KDM4E (0.44) | ALDH1A1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL16214779 | 0.79 | KDM4E (0.32) | KDM4EGLAGAA | |
| SCHEMBL18236156 | 0.79 | ALOX15 (0.45) | GAACCNCCDK8HTTLIMK1 | |
| SCHEMBL3576164 | 0.77 | MAP2K1 (0.46) | NNMTALDH1A1KDM4EGLAGAA | |
| SCHEMBL30846960 | 0.75 | PTPN11 (0.41) | KDM4EGLAGAAMKNK1MAP2K1 | |
| SCHEMBL30086887 | 0.75 | KDM4E (0.42) | NNMTALDH1A1KDM4EGLAGAA | |
| SCHEMBL29063211 | 0.71 | — | — | |
| SCHEMBL27912682 | 0.71 | MAP2K1 (0.39) | NNMTALDH1A1KDM4EGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100099726-A1 | INHIBITORS OF PYRUVATE KINASE AND METHODS OF TREATING DISEASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099726-A1 | INHIBITORS OF PYRUVATE KINASE AND METHODS OF TREATING DISEASE | PDK1, PDK4, PDK3 | NNMT 781/4885ALDH1A1 978/4885KDM4E 1017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.