Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19266744 | 0.85 | KDM4E (0.41) | SMN1; SMN2KDM4EALDH1A1RAB9ALMNA | |
| SCHEMBL14621112 | 0.85 | KDM4E (0.41) | SMN1; SMN2KDM4EALDH1A1RAB9ALMNA | |
| SCHEMBL14621091 | 0.80 | CYP1A2 (0.40) | SMN1; SMN2KDM4EALDH1A1RAB9ALMNA | |
| SCHEMBL1342487 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1RAB9ALMNAHPGD | |
| SCHEMBL3988008 | 0.77 | ALDH1A1 (0.51) | SMN1; SMN2KDM4EALDH1A1RAB9ALMNA | |
| SCHEMBL1342873 | 0.75 | ALDH1A1 (0.47) | SMN1; SMN2KDM4EALDH1A1RAB9ALMNA | |
| SCHEMBL16378090 | 0.75 | ALDH1A1 (0.49) | SMN1; SMN2KDM4EALDH1A1RAB9ALMNA | |
| SCHEMBL12164343 | 0.74 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL1343386 | 0.73 | KDM4E (0.51) | SMN1; SMN2KDM4EALDH1A1RAB9ALMNA | |
| SCHEMBL20749127 | 0.73 | SMN1; SMN2 (0.46) | SMN1; SMN2KDM4EALDH1A1RAB9AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063067-B2 | Hexenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic applications thereof | MERCK PATENT GMBH (DE) | 2011-11-22 | — | — | US | disclosed |
| US-7632846-B2 | the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and processes for the preparation of these | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER (DE) | 2009-12-15 | — | — | US | disclosed |
| US-20090286776-A1 | HEXENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF | ZEILLER JEAN JACQUES | 2009-11-19 | — | — | US | disclosed |
| US-20080194564-A1 | Hexenoic Acid Derivatives, Processes for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Applications Thereof | MERCK PATENT GMBH (DE) | 2008-08-14 | — | — | US | disclosed |
| EP-1742902-B1 | HEXENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF | MERCK PATENT GMBH (DE) | 2007-09-26 | — | — | EP | disclosed |
| EP-1742902-A1 | HEXENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF | MERCK PATENT GmbH (DE) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005105724-A1 | HEXENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF | MERCK PATENT GMBH (DE) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194564-A1 | Hexenoic Acid Derivatives, Processes for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Applications Thereof | GPR119, LIPA, ALOX5 | SMN1; SMN2 3678/4885KDM4E 4194/4885ALDH1A1 692/4885 |
| US-20090286776-A1 | HEXENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF | GPR119, LIPA, ALOX5 | SMN1; SMN2 3678/4885KDM4E 4194/4885ALDH1A1 692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.