Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT1 | P34896 | 1/20 | 0.53 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3417224 | 0.87 | SHMT1 (0.53) | SHMT1SHMT2TMEM97SIGMAR1HPGD | |
| SCHEMBL3413959 | 0.85 | SHMT1 (0.49) | SHMT1SHMT2TMEM97SIGMAR1MEN1 | |
| SCHEMBL13433490 | 0.81 | GAA (0.47) | TMEM97SIGMAR1HPGDMEN1KMT2A | |
| SCHEMBL13433426 | 0.81 | PPARD (0.47) | SHMT1SHMT2TMEM97SIGMAR1HPGD | |
| SCHEMBL13433439 | 0.78 | PTPN11 (0.50) | MEN1KMT2APPARDL3MBTL1 | |
| SCHEMBL3414382 | 0.78 | ACLY (0.55) | PPARDSMN1; SMN2FLT1FLT4KDR | |
| SCHEMBL3418619 | 0.77 | SCN2A (0.45) | SHMT1SHMT2TMEM97SIGMAR1HPGD | |
| SCHEMBL23296156 | 0.76 | SHMT1 (0.74) | SHMT1SHMT2PLA2G10PLA2G2A | |
| SCHEMBL3413969 | 0.76 | GAA (0.52) | HPGDPPARDNPC1RAB9AALDH1A1 | |
| SCHEMBL13812806 | 0.76 | CDK1 (0.56) | HPGDMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |