Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDAH1 | O94760 | 7/20 | 0.54 |
| ▸ | NOS2 | P35228 | 8/20 | 0.54 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.53 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.53 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | NOS1 | P29475 | 8/20 | 0.51 |
| ▸ | NOS3 | P29474 | 5/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5306351 | 0.88 | DDAH1 (0.56) | DDAH1NOS2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL1344676 | 0.88 | DDAH1 (0.56) | DDAH1NOS2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL7444455 | 0.82 | DDAH1 (0.68) | DDAH1NOS2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL29381881 | 0.82 | DDAH1 (0.68) | DDAH1NOS2GRIN2DGRIN3BGRIN1 | |
| Lactic Acid SCHEMBL6015489 | 0.81 | GRIN2D (0.58) | DDAH1GRIN2DGRIN3BGRIN1GRIN2A | |
| Acetic Acid SCHEMBL6015501 | 0.80 | GRIN2D (0.66) | DDAH1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL5330864 | 0.78 | DDAH1 (0.52) | DDAH1NOS2NOS1NOS3CYP1A2 | |
| SCHEMBL1345153 | 0.78 | DDAH1 (0.52) | DDAH1NOS2NOS1NOS3CYP1A2 | |
| SCHEMBL1343476 | 0.78 | DDAH1 (0.52) | DDAH1NOS2NOS1NOS3CYP1A2 | |
| SCHEMBL1345491 | 0.78 | DDAH1 (0.52) | DDAH1NOS2NOS1NOS3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828109-B1 | GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH | UCL BUSINESS PLC (GB) | 2013-06-05 | — | — | EP | disclosed |
| US-8063104-B2 | Guanidine derivatives as inhibitors of DDAH | UCL BUSINESS PLC (GB) | 2011-11-22 | — | — | US | disclosed |
| US-20090069331-A1 | GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH | UCL Biomedica PLC c/o Finance Division University College of London (GB) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069331-A1 | GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH | DDAH1, DOHH, IMPDH1 | DDAH1 1/4885NOS2 644/4885GRIN2D 2900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.