Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDAH1 | O94760 | 7/20 | 0.68 |
| ▸ | NOS1 | P29475 | 8/20 | 0.54 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.51 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.51 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.51 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | NOS2 | P35228 | 8/20 | 0.51 |
| ▸ | NOS3 | P29474 | 5/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29381881 | 1.00 | DDAH1 (0.68) | DDAH1NOS1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL5306351 | 0.91 | DDAH1 (0.56) | DDAH1NOS1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL1344676 | 0.91 | DDAH1 (0.56) | DDAH1NOS1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL1343418 | 0.82 | DDAH1 (0.54) | DDAH1NOS1GRIN2DGRIN3BGRIN1 | |
| Tilarginine SCHEMBL349879 | 0.81 | DDAH1 (0.58) | DDAH1NOS1NOS2NOS3CYP2C19 | |
| Tilarginine SCHEMBL10198569 | 0.81 | DDAH1 (0.58) | DDAH1NOS1NOS2NOS3CYP2C19 | |
| Tilarginine SCHEMBL1736031 | 0.81 | DDAH1 (0.58) | DDAH1NOS1NOS2NOS3CYP2C19 | |
| Tilarginine SCHEMBL7450191 | 0.81 | DDAH1 (0.58) | DDAH1NOS1NOS2NOS3CYP2C19 | |
| Tilarginine SCHEMBL31106009 | 0.80 | DDAH1 (0.57) | DDAH1NOS1NOS2NOS3CYP2C19 | |
| Tilarginine SCHEMBL29711436 | 0.80 | DDAH1 (0.57) | DDAH1NOS1NOS2NOS3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240018230-A1 | METHODS FOR TREATING OR MODULATING AN INFLAMMATORY RESPONSE | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. | 2024-01-18 | — | — | US | disclosed |
| US-11446398-B2 | Regulated biocircuit systems | OBSIDIAN THERAPEUTICS, INC. (US) | 2022-09-20 | — | — | US | disclosed |
| EP-0669824-A1 | USE OF CARDIOTONIC DRUGS AND INHIBITORS OF NITRIC OXIDE SYNTHESIS TO ALLEVIATE PATHOLOGIC HYPOTENSION | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1995-09-06 | — | — | EP | disclosed |
| EP-0669824-A4 | USE OF CARDIOTONIC DRUGS AND INHIBITORS OF NITRIC OXIDE SYNTHESIS TO ALLEVIATE PATHOLOGIC HYPOTENSION. | UNIV TEXAS (US) | 1995-07-25 | — | — | EP | disclosed |
| WO-1993024122-A1 | USE OF CARDIOTONIC DRUGS AND INHIBITORS OF NITRIC OXIDE SYNTHESIS TO ALLEVIATE PATHOLOGIC HYPOTENSION | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1993-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240018230-A1 | METHODS FOR TREATING OR MODULATING AN INFLAMMATORY RESPONSE | IFNG, TNF, IL2 | DDAH1 1785/4885NOS1 822/4885GRIN2D 4357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.