Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH2 | P05091 | 19/20 | 0.60 |
| ▸ | MAOA | P21397 | 11/20 | 0.57 |
| ▸ | MAOB | P27338 | 11/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14326202 | 0.93 | MAPT (0.52) | ALDH2MAOAMAOBEGFR | |
| SCHEMBL3591660 | 0.76 | ALDH2 (1.00) | ALDH2MAOAMAOB | |
| SCHEMBL1701071 | 0.74 | ALDH2 (0.93) | ALDH2MAOAMAOB | |
| SCHEMBL2108188 | 0.74 | ALDH2 (0.62) | ALDH2MAOAMAOBEGFR | |
| SCHEMBL1701078 | 0.74 | ALDH2 (1.00) | ALDH2MAOAMAOB | |
| SCHEMBL10624708 | 0.74 | ALDH2 (1.00) | ALDH2MAOAMAOB | |
| SCHEMBL1701152 | 0.74 | ALDH2 (1.00) | ALDH2MAOAMAOB | |
| SCHEMBL4686444 | 0.73 | ALDH2 (1.00) | ALDH2MAOAMAOB | |
| SCHEMBL4679869 | 0.73 | ALDH2 (1.00) | ALDH2MAOAMAOB | |
| SCHEMBL4684115 | 0.73 | ALDH2 (1.00) | ALDH2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338624-B2 | Isoflavone derivatives and uses thereof | YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) | 2012-12-25 | — | — | US | disclosed |
| US-8338624-B2 | Isoflavone derivatives and uses thereof | YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) | 2012-12-25 | — | — | US | disclosed |
| US-20100069478-A1 | ISOFLAVONE DERIVATIVES AND USES THEREOF | YEDA RESEARCH AND DEVELOPMENT CO, LTD. (IL) | 2010-03-18 | — | — | US | disclosed |
| US-20100069478-A1 | ISOFLAVONE DERIVATIVES AND USES THEREOF | YEDA RESEARCH AND DEVELOPMENT CO, LTD. (IL) | 2010-03-18 | — | — | US | disclosed |
| WO-2008102350-A1 | ISOFLAVONE DERIVATIVES AND USES THEREOF | YEDA RESEARCH AND DEVELOPMENT CO. LTD (IL) | 2008-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069478-A1 | ISOFLAVONE DERIVATIVES AND USES THEREOF | SHBG, CYP19A1, GPER1 | ALDH2 2737/4885MAOA 689/4885MAOB 319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.