⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6782280 | 1.00 | — | — | |
| SCHEMBL15177569 | 0.85 | ALDH1A1 (0.30) | — | |
| SCHEMBL23619583 | 0.84 | — | — | |
| SCHEMBL18500728 | 0.83 | ALDH1A1 (0.35) | — | |
| Toluene SCHEMBL4089210 | 0.78 | LMNA (0.44) | — | |
| SCHEMBL62598 | 0.73 | — | — | |
| SCHEMBL19774902 | 0.72 | DNM1 (0.31) | — | |
| SCHEMBL21911602 | 0.71 | — | — | |
| SCHEMBL18384525 | 0.71 | — | — | |
| SCHEMBL12888006 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2479 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119552158-A | Preparation method of GLP-1 receptor agonist Orforglipron | 河南省科学院化学研究所 | 2025-03-04 | — | — | CN | claimed |
| CN-117843505-A | N, N-dimethylformamide di-tert-butyl acetal and preparation method thereof | 常熟泓德生物科技有限公司 | 2024-04-09 | — | — | CN | claimed |
| US-11274081-B2 | Process for the synthesis of ivacaftor | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2022-03-15 | — | — | US | claimed |
| US-20210300935-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | Nerviano Medical Sciences, S.R.L. (IT) | 2021-09-30 | — | — | US | claimed |
| US-20200325104-A1 | AN IMPROVED PROCESS FOR THE SYNTHESIS OF IVACAFTOR | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2020-10-15 | — | — | US | claimed |
| EP-3464243-A2 | AN IMPROVED PROCESS FOR THE SYNTHESIS OF IVACAFTOR | Council of Scientific and Industrial Research (IN) | 2019-04-10 | — | — | EP | claimed |
| CN-108653822-A | A kind of degradable visual inner locking type femoral interlocking nail | 温州市中心医院 | 2018-10-16 | — | — | CN | claimed |
| WO-2017208253-A2 | AN IMPROVED PROCESS FOR THE SYNTHESIS OF IVACAFTOR | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-12-07 | — | — | WO | claimed |
| EP-2796461-B1 | METHODS OF PREPARING ICOTINIB AND ICOTINIB HYDROCHLORIDE, AND INTERMEDIATES THEREOF | BETTA PHARMACEUTICALS CO LTD (CN) | 2017-09-06 | — | — | EP | claimed |
| US-9637497-B2 | Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | Nerviano Medical Sciences, S.R.L. (IT) | 2017-05-02 | — | — | US | claimed |
| CN-101563351-A | Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2009-10-21 | — | — | CN | claimed |
| US-20090124605-A1 | Pyrazolo-Quinazoline Derivatives, Process for Their Preparation and Their Use as Kinase Inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-05-14 | — | — | US | claimed |
| US-20070185143-A1 | Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-08-09 | — | — | US | claimed |
| JP-2007502851-A | — | — | 2007-02-15 | — | — | JP | claimed |
| CN-1826343-A | Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | PHARMACIA ITALIA SPA (IT) | 2006-08-30 | — | — | CN | claimed |
| EP-1636236-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2006-03-22 | — | — | EP | claimed |
| WO-2004104007-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2004-12-02 | — | — | WO | claimed |
| US-5248760-A | CHEMICALLY CURED LOW TEMPERATURE POLYIMIDES | UNC AT CHARLOTTE (US) | 1993-09-28 | — | — | US | claimed |
| WO-1992013024-A1 | CHEMICALLY CURED LOW TEMPERATURE POLYIMIDES | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE (US) | 1992-08-06 | — | — | WO | claimed |
| US-4698436-A | Processes for the preparation of spectinomycin analogs, novel products and intermediates therein | THE UPJOHN COMPANY (US) | 1987-10-06 | — | — | US | claimed |