Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 9/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD4 | P21917 | 2/20 | 0.31 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1343091 | 0.75 | MAOA (0.38) | CYP2D6SETD7NPC1 | |
| SCHEMBL30171415 | 0.71 | P2RX4 (0.35) | P2RX4KDM4EDRD2DRD4SMN1; SMN2 | |
| SCHEMBL1343635 | 0.70 | P2RX4 (0.35) | P2RX4CYP1A2CYP2D6SETD7KDM4E | |
| SCHEMBL1344339 | 0.68 | DRD2 (0.38) | P2RX4CYP1A2CYP2D6SETD7KDM4E | |
| SCHEMBL5655144 | 0.65 | ABCG2 (0.32) | — | |
| SCHEMBL2854510 | 0.64 | P2RX4 (0.35) | P2RX4 | |
| SCHEMBL28769772 | 0.62 | CYP1A2 (0.56) | P2RX4CYP1A2CYP2D6SETD7KDM4E | |
| SCHEMBL10586348 | 0.61 | P2RX4 (0.48) | P2RX4P2RX1P2RX3SMN1; SMN2 | |
| SCHEMBL19537981 | 0.59 | MAPK1 (0.61) | P2RX4CYP1A2CYP2D6SETD7KDM4E | |
| SCHEMBL5693983 | 0.59 | MAPK1 (0.61) | P2RX4CYP1A2CYP2D6SETD7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155757-B1 | NEW PROGESTERONE RECEPTOR MODULATORS | MSD OSS BV (NL) | 2012-10-31 | — | — | EP | disclosed |
| US-8063037-B2 | Progesterone receptor modulators | N. V. ORGANON (NL) | 2011-11-22 | — | — | US | disclosed |
| US-20090054400-A1 | NEW PROGESTERONE RECEPTOR MODULATORS | N.V. ORGANON | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054400-A1 | NEW PROGESTERONE RECEPTOR MODULATORS | PGR, PGRMC2, PGRMC1 | P2RX4 285/4885CYP1A2 449/4885CYP2D6 534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.