Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 8/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 8/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13438562 | 0.84 | MTNR1A (0.43) | HTTMAPK1KDM4EALDH1A1LMNA | |
| SCHEMBL13438553 | 0.82 | SIGMAR1 (0.37) | HRH1SIGMAR1HTTHTR2CKDM4E | |
| SCHEMBL8266687 | 0.77 | KDM4E (0.45) | HTTCHRM2CHRM1CHRM3KDM4E | |
| SCHEMBL2982482 | 0.76 | SIGMAR1 (0.43) | HRH1SIGMAR1HTTHTR2CKDM4E | |
| SCHEMBL2979728 | 0.76 | SIGMAR1 (0.45) | SIGMAR1DRD2DRD3ALDH1A1 | |
| SCHEMBL17075090 | 0.68 | SIGMAR1 (0.37) | CARM1PRMT6SIGMAR1KCNH2ALDH1A1 | |
| SCHEMBL17075097 | 0.65 | SIGMAR1 (0.45) | SIGMAR1CYP1A2CYP3A4CYP2D6DRD2 | |
| SCHEMBL12938774 | 0.65 | SRD5A1 (0.45) | HRH1 | |
| SCHEMBL4612112 | 0.64 | HTR2A (0.41) | HRH1SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL8268501 | 0.62 | KDM1A (0.42) | HTTKDM4EALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7671196-B2 | Diazepinoquinolines, synthesis thereof, and intermediates thereto | WYETH LLC (US) | 2010-03-02 | — | — | US | disclosed |
| US-20070088022-A1 | Tetrahydroquinolines, synthesis thereof, and intermediates thereto | WYETH (US) | 2007-04-19 | — | — | US | disclosed |
| US-20070027142-A1 | Diazepinoquinolines, synthesis thereof, and intermediates thereto | WYETH (US) | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070088022-A1 | Tetrahydroquinolines, synthesis thereof, and intermediates thereto | HTR2C, HTR3B, HTR2A | HRH1 239/4885CARM1 2931/4885PRMT6 3519/4885 |
| US-20070027142-A1 | Diazepinoquinolines, synthesis thereof, and intermediates thereto | HTR2C, HTR3B, HTR2A | HRH1 92/4885CARM1 2650/4885PRMT6 4070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.