Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 9/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 9/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | CACNA1I | Q9P0X4 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17075097 | 0.85 | SIGMAR1 (0.45) | SIGMAR1CACNA1GCACNA1HBRD4CACNA1I | |
| SCHEMBL13438553 | 0.79 | SIGMAR1 (0.37) | SIGMAR1ALDH1A1 | |
| SCHEMBL8266687 | 0.78 | KDM4E (0.45) | BRD4ALDH1A1SIRT1 | |
| SCHEMBL13438554 | 0.76 | HRH1 (0.41) | SIGMAR1ALDH1A1DRD2DRD3 | |
| SCHEMBL6508105 | 0.76 | ALDH1A1 (0.59) | ALDH1A1 | |
| SCHEMBL7496682 | 0.75 | BRD4 (0.55) | CACNA1GCACNA1HBRD4CACNA1ISIRT1 | |
| SCHEMBL7496685 | 0.75 | BRD4 (0.55) | CACNA1GCACNA1HBRD4CACNA1ISIRT1 | |
| Hydrochloric Acid SCHEMBL7504712 | 0.74 | BRD4 (0.54) | CACNA1GCACNA1HBRD4CACNA1ISIRT1 | |
| SCHEMBL7502809 | 0.73 | ALOX12 (0.49) | CACNA1GCACNA1HBRD4CACNA1ISIRT1 | |
| SCHEMBL7502803 | 0.73 | ALOX12 (0.49) | CACNA1GCACNA1HBRD4CACNA1ISIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781427-B2 | Process for preparing quinoline compounds and products obtained therefrom | WYETH LLC (US) | 2010-08-24 | — | — | US | disclosed |
| US-20100196714-A1 | PROCESS FOR PREPARING QUINOLINE COMPOUNDS AND PRODUCTS OBTAINED THEREFROM | WYETH (US) | 2010-08-05 | — | — | US | disclosed |
| EP-1807428-A2 | PROCESS FOR PREPARING QUINOLINE COMPOUNDS AND PRODUCTS OBTAINED THEREFROM | Wyeth (US) | 2007-07-18 | — | — | EP | disclosed |
| US-20060122385-A1 | Process for preparing quinoline compounds and products obtained therefrom | WYETH (US) | 2006-06-08 | — | — | US | disclosed |
| WO-2006052768-A2 | PROCESS FOR PREPARING QUINOLINE COMPOUNDS AND PRODUCTS OBTAINED THEREFROM | WYETH (US) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122385-A1 | Process for preparing quinoline compounds and products obtained therefrom | NNMT, QTRT1, HNMT | SIGMAR1 2811/4885CACNA1G 3454/4885CACNA1H 3544/4885 |
| US-20100196714-A1 | PROCESS FOR PREPARING QUINOLINE COMPOUNDS AND PRODUCTS OBTAINED THEREFROM | NNMT, QTRT1, HNMT | SIGMAR1 2811/4885CACNA1G 3454/4885CACNA1H 3544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.