Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.35 |
| ▸ | MEN1 | O00255 | 6/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21931405 | 0.74 | ALDH1A1 (0.47) | ALDH1A1LMNANOTUMMAPTPOLB | |
| SCHEMBL13440540 | 0.72 | NOTUM (0.47) | ALDH1A1LMNANOTUMMAPTPOLB | |
| SCHEMBL27515051 | 0.65 | KDM4E (0.48) | ALDH1A1LMNAMAPTPOLBKMT2A | |
| SCHEMBL4763682 | 0.65 | ALDH1A1 (0.49) | ALDH1A1LMNANOTUMMAPTPOLB | |
| SCHEMBL25778900 | 0.63 | ALDH1A1 (0.39) | ALDH1A1LMNANOTUMMAPTNPC1 | |
| SCHEMBL21929115 | 0.62 | ALDH1A1 (0.41) | ALDH1A1LMNANOTUMMAPTPOLB | |
| SCHEMBL338465 | 0.61 | RIPK1 (0.43) | ALDH1A1LMNANOTUMMAPTNPC1 | |
| SCHEMBL13440545 | 0.60 | NOTUM (0.40) | ALDH1A1LMNANOTUMMAPTPOLB | |
| SCHEMBL13990291 | 0.60 | ALDH1A1 (0.57) | ALDH1A1LMNANOTUMMAPTPOLB | |
| SCHEMBL25886649 | 0.59 | ALDH1A1 (0.39) | ALDH1A1LMNANOTUMMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069380-A1 | HETEROCYCLIC INHIBITORS OF BACTERIAL PEPTIDYL TRNA HYDROLASE AND USES THEREOF | PTC THERAPEUTICS, INC. | 2010-03-18 | — | — | US | disclosed |
| US-20100069380-A1 | HETEROCYCLIC INHIBITORS OF BACTERIAL PEPTIDYL TRNA HYDROLASE AND USES THEREOF | PTC THERAPEUTICS, INC. | 2010-03-18 | — | — | US | disclosed |
| WO-2008127274-A2 | HETEROCYCLIC INHIBITORS OF BACTERIAL PEPTIDYL TRNA HYDROLASE AND USES THEREOF | PTC THERAPEUTICS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069380-A1 | HETEROCYCLIC INHIBITORS OF BACTERIAL PEPTIDYL TRNA HYDROLASE AND USES THEREOF | NSUN3, TARBP1, TRMT1 | ALDH1A1 3494/4885LMNA 2706/4885NOTUM 3574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.