Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13440539 | 0.92 | ALDH1A1 (0.57) | ALDH1A1KMT2AMEN1POLBTSHR | |
| SCHEMBL3606590 | 0.92 | ALDH1A1 (0.54) | ALDH1A1KMT2AMEN1POLBTSHR | |
| SCHEMBL13440579 | 0.90 | ALDH1A1 (0.55) | ALDH1A1KMT2AMEN1POLBTSHR | |
| SCHEMBL3600700 | 0.90 | KMT2A (0.52) | ALDH1A1KMT2AMEN1POLBTSHR | |
| SCHEMBL13441119 | 0.90 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1POLBTSHR | |
| SCHEMBL13440774 | 0.89 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1POLBTSHR | |
| SCHEMBL4597039 | 0.88 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1POLBTSHR | |
| SCHEMBL3600696 | 0.87 | ALDH1A1 (0.49) | ALDH1A1KMT2AMEN1POLBTSHR | |
| SCHEMBL13440778 | 0.87 | ALDH1A1 (0.49) | ALDH1A1KMT2AMEN1POLBTSHR | |
| SCHEMBL13441023 | 0.87 | KMT2A (0.49) | ALDH1A1KMT2AMEN1POLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069380-A1 | HETEROCYCLIC INHIBITORS OF BACTERIAL PEPTIDYL TRNA HYDROLASE AND USES THEREOF | PTC THERAPEUTICS, INC. | 2010-03-18 | — | — | US | disclosed |
| US-20100069380-A1 | HETEROCYCLIC INHIBITORS OF BACTERIAL PEPTIDYL TRNA HYDROLASE AND USES THEREOF | PTC THERAPEUTICS, INC. | 2010-03-18 | — | — | US | disclosed |
| WO-2008127274-A2 | HETEROCYCLIC INHIBITORS OF BACTERIAL PEPTIDYL TRNA HYDROLASE AND USES THEREOF | PTC THERAPEUTICS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069380-A1 | HETEROCYCLIC INHIBITORS OF BACTERIAL PEPTIDYL TRNA HYDROLASE AND USES THEREOF | NSUN3, TARBP1, TRMT1 | ALDH1A1 3494/4885KMT2A 2284/4885MEN1 4179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.