Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24073689 | 0.81 | PARP1 (0.42) | MEN1KMT2A | |
| SCHEMBL818385 | 0.81 | ADRA2A (0.33) | MEN1MAPTKMT2A | |
| SCHEMBL15704285 | 0.79 | CHRNB4 (0.48) | PBRM1DDB1CRBNCNR2SMN1; SMN2 | |
| SCHEMBL29932760 | 0.76 | NOTUM (0.42) | DDB1CRBNCNR2SMN1; SMN2KDM4E | |
| SCHEMBL16025390 | 0.76 | NOTUM (0.42) | DDB1CRBNCNR2SMN1; SMN2KDM4E | |
| SCHEMBL28966471 | 0.74 | DRD2 (0.44) | — | |
| SCHEMBL2442839 | 0.73 | PTGDR2 (0.45) | ALDH1A1POLBHPGDMEN1MAPT | |
| SCHEMBL17681983 | 0.73 | CYP2D6 (0.43) | DDB1CRBNALDH1A1NOTUMHPGD | |
| SCHEMBL7670262 | 0.73 | HTR2C (0.56) | — | |
| SCHEMBL20656815 | 0.72 | KDM1A (0.48) | KDM4ELMNAHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038465-A1 | 8-SUBSTITUTED ISOQUINOLINE DERIVATIVE AND USE THEREOF | 旭化成ファーマ株式会社 (JP) | 2010-04-08 | — | — | WO | disclosed |