Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | TRPC5 | Q9UL62 | 3/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1263985 | 0.82 | NOTUM (0.40) | KCNH2NOTUMTRPC5PDE10ADRD2 | |
| SCHEMBL1346658 | 0.82 | ALDH1A1 (0.50) | NOTUM | |
| SCHEMBL8139457 | 0.82 | KCNH2 (0.43) | KCNH2NOTUMCHRM5PDE10ARXRA | |
| SCHEMBL4282578 | 0.79 | HTT (0.51) | NOTUM | |
| SCHEMBL9292198 | 0.77 | HSP90AA1 (0.49) | NOTUM | |
| SCHEMBL747392 | 0.72 | NOTUM (0.47) | NOTUMDRD3 | |
| SCHEMBL1344141 | 0.72 | TRPV1 (0.43) | — | |
| SCHEMBL16474556 | 0.71 | PDE10A (0.48) | NOTUMTRPC5CHRM5PDE10AXDH | |
| SCHEMBL13907450 | 0.71 | MAPT (0.49) | KCNH2 | |
| SCHEMBL16474565 | 0.70 | PDE10A (0.42) | TRPC5CHRM5PDE10AMCHR1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063055-B2 | Substituted pyridone compounds and methods of use | AMGEN INC. (US) | 2011-11-22 | — | — | US | disclosed |