Esafloxacin

Esafloxacin

SCHEMBL1344407

CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCC(N)C3)nc21

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.69
CYP2C9 P11712 1/20 0.69
ATP6V1B2 P21281 1/20 0.69
TBXA2R P21731 1/20 0.69
EDNRA P25101 1/20 0.69
TARBP2 Q15633 1/20 0.69
KMT2A Q03164 2/20 0.67
TOP1 P11387 3/20 0.51
DPP4 P27487 5/20 0.50
EPHA2 P29317 1/20 0.50
FLT4 P35916 1/20 0.50
GSK3B P49841 1/20 0.50
RARB P10826 1/20 0.50
TBXAS1 P24557 1/20 0.50
SLC6A3 Q01959 1/20 0.50
ALDH1A1 P00352 3/20 0.49
CHRM2 P08172 2/20 0.49
POLB P06746 2/20 0.49
CHRM1 P11229 1/20 0.49
OPRM1 P35372 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Esafloxacin SCHEMBL1231132 0.99 LMNA (0.68) LMNACYP2C9ATP6V1B2TBXA2REDNRA
SCHEMBL10677290 0.92 LMNA (0.71) LMNACYP2C9ATP6V1B2TBXA2REDNRA
SCHEMBL9044893 0.90 KMT2A (0.67) LMNACYP2C9ATP6V1B2TBXA2REDNRA
SCHEMBL9437345 0.89 LMNA (0.67) LMNACYP2C9ATP6V1B2TBXA2REDNRA
Hydrochloric Acid SCHEMBL10669137 0.88 LMNA (0.66) LMNACYP2C9ATP6V1B2TBXA2REDNRA
SCHEMBL9437381 0.88 LMNA (0.66) LMNACYP2C9ATP6V1B2TBXA2REDNRA
SCHEMBL9437379 0.88 LMNA (0.66) LMNACYP2C9ATP6V1B2TBXA2REDNRA
SCHEMBL11165875 0.87 LMNA (0.67) LMNACYP2C9ATP6V1B2TBXA2REDNRA
SCHEMBL9437352 0.86 LMNA (0.72) LMNACYP2C9ATP6V1B2TBXA2REDNRA
Hydrochloric Acid SCHEMBL10658429 0.86 LMNA (0.66) LMNACYP2C9ATP6V1B2TBXA2REDNRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 159 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119894504-A Inhalable formulation for treating bacterial infections in the lungs 索米克生物技术有限公司 2025-04-25 CN claimed
CN-118340907-A Polymer conjugates comprising bioactive agents 波利艾克蒂瓦有限公司 2024-07-16 CN claimed
US-20230285572-A1 TARGETED DELIVERY OF THERAPEUTIC AGENTS SEPELO THERAPEUTICS, LLC 2023-09-14 US claimed
EP-4188433-A2 TARGETED DELIVERY OF THERAPEUTIC AGENTS Sepelo Therapeutics, LLC (US) 2023-06-07 EP claimed
WO-2023028364-A1 TARGETED COMPOSITIONS AND USES THEROF SEPELO THERAPEUTICS, LLC (US) 2023-03-02 WO claimed
CN-110898061-B An antibacterial agent suitable for oral administration to animals 广州自远生物科技有限公司 2022-04-15 CN claimed
CN-109996804-B Squalamine amide derivatives for the treatment of infections 维克公司 2022-04-08 CN claimed
WO-2022031761-A2 TARGETED DELIVERY OF THERAPEUTIC AGENTS SEPELO THERAPEUTICS, LLC (US) 2022-02-10 WO claimed
EP-2961730-A2 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XenoPort, Inc. (US) 2016-01-06 EP claimed
US-20150158809-A9 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XENOPORT, INC. (US) 2015-06-11 US claimed
US-20140243544-A1 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XENOPORT, INC. (US) 2014-08-28 US claimed
US-8299291-B2 Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs XENOPORT, INC. (US) 2012-10-30 US claimed
US-8062870-B2 Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs XENOPORT, INC. (US) 2011-11-22 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-0027752-B1 NAPHTHYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Société anonyme dite: LABORATOIRE ROGER BELLON (FR) 1983-12-21 EP claimed
US-4341784-A BACTERICIDES DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 1982-07-27 US claimed
EP-0027752-A1 Naphthyridine derivatives, processes for their preparation and pharmaceutical compositions containing them Société anonyme dite: LABORATOIRE ROGER BELLON (FR) 1981-04-29 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150158809-A9 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS CPS1, CA7, NAAA LMNA 2248/4885CYP2C9 98/4885ATP6V1B2 1340/4885
US-20140243544-A1 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS CPS1, CA7, NAAA LMNA 2248/4885CYP2C9 98/4885ATP6V1B2 1340/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.