Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.56 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.56 |
| ▸ | EDNRA | P25101 | 1/20 | 0.56 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.56 |
| ▸ | DPP4 | P27487 | 6/20 | 0.52 |
| ▸ | TOP1 | P11387 | 3/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | RARB | P10826 | 1/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Esafloxacin SCHEMBL1344407 | 0.90 | LMNA (0.69) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| Esafloxacin SCHEMBL1231132 | 0.90 | LMNA (0.68) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| SCHEMBL2095390 | 0.89 | KMT2A (0.63) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| SCHEMBL2093446 | 0.88 | KMT2A (0.62) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| SCHEMBL11196749 | 0.86 | LMNA (0.56) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| SCHEMBL11198791 | 0.86 | LMNA (0.56) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| SCHEMBL2095084 | 0.86 | KMT2A (0.62) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| SCHEMBL2092021 | 0.86 | KMT2A (0.61) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| SCHEMBL2090820 | 0.86 | KMT2A (0.64) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| SCHEMBL9838735 | 0.84 | KMT2A (0.69) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-57146775-A | — | — | None | — | — | JP | disclosed |
| EP-0360258-B1 | Amino acid quinoline and naphthyridine derivatives | ABBOTT LAB (US) | 1996-08-14 | — | — | EP | disclosed |
| US-5057520-A | Water solubility | ABBOTT LABORATORIES (US) | 1991-10-15 | — | — | US | disclosed |
| US-5057523-A | Water soluble bactericide | ABBOTT LABORATORIES (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0360258-A2 | Amino acid quinoline and naphthyridine derivatives | ABBOTT LABORATORIES (US) | 1990-03-28 | — | — | EP | disclosed |
| US-4382937-A | Naphthyridine derivatives and their use as anti-bacterials | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1983-05-10 | — | — | US | disclosed |
| JP-S57146775-A | 1,8-NAPHTHYRIDINE DERIVATIVE AND ITS SALT | DAINIPPON PHARMACEUT CO LTD | 1982-09-10 | — | — | JP | disclosed |