Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.67 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | BCL9 | O00512 | 12/20 | 0.62 |
| ▸ | CTNNB1 | P35222 | 12/20 | 0.62 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.55 |
| ▸ | TUBB | P07437 | 2/20 | 0.55 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.55 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.55 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.55 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988273 | 0.89 | ABCB1 (0.78) | KDM4EMEN1ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL13464140 | 0.88 | ABCG2 (0.60) | KDM4EMEN1ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL1764425 | 0.83 | KDM4E (0.74) | KDM4EABCB1ABCG2GAAMAPT | |
| SCHEMBL30819242 | 0.83 | KDM4E (0.74) | KDM4EABCB1ABCG2GAAMAPT | |
| SCHEMBL25221318 | 0.82 | ABCG2 (0.78) | KDM4EMEN1ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL24895133 | 0.81 | KDM4E (0.67) | KDM4ECYP3A4ABCB1ABCG2GAA | |
| SCHEMBL17179788 | 0.81 | MEN1 (1.00) | KDM4EMEN1ALDH1A1CYP3A4MAPK1 | |
| 3,5,6,7,8,3',4'-Heptamethoxyflavone SCHEMBL29467229 | 0.80 | ABCG2 (1.00) | KDM4EMEN1ALDH1A1CYP3A4MAPK1 | |
| 3,5,6,7,8,3',4'-Heptamethoxyflavone SCHEMBL1764676 | 0.80 | ABCG2 (1.00) | KDM4EMEN1ALDH1A1CYP3A4MAPK1 | |
| 3,5,6,7,8,3',4'-Heptamethoxyflavone SCHEMBL31621487 | 0.80 | ABCG2 (1.00) | KDM4EMEN1ALDH1A1CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683095-B2 | Compositions and methods of treating, reducing and preventing cardiovascular diseases and disorders with polymethoxyflavones | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 2010-03-23 | — | — | US | disclosed |