Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL203637 | 0.77 | MEN1 (0.44) | MEP1BTUBB1MEN1KMT2AMAPK1 | |
| SCHEMBL29411714 | 0.77 | MEN1 (0.44) | MEP1BTUBB1MEN1KMT2AMAPK1 | |
| SCHEMBL1344860 | 0.77 | STING1 (0.36) | STING1AKR1C3AKR1C2AKR1C1PTGS1 | |
| SCHEMBL143557 | 0.77 | MEP1B (0.42) | STING1AKR1C3AKR1C2PPARDPPARA | |
| SCHEMBL3869745 | 0.74 | MEN1 (0.37) | STING1MEP1BTUBB1FFAR1FFAR4 | |
| SCHEMBL202056 | 0.73 | TSHR (0.38) | STING1MEP1BTUBB1MEN1KMT2A | |
| SCHEMBL1344949 | 0.71 | PKM (0.46) | MEN1KMT2A | |
| SCHEMBL28583415 | 0.71 | MEN1 (0.42) | TUBB1MEN1KMT2AMAPK1 | |
| SCHEMBL11661009 | 0.69 | MAPK1 (0.55) | TUBB1MEN1KMT2AL3MBTL1MAPK1 | |
| SCHEMBL4483431 | 0.68 | HTT (0.62) | PPARDPPARAMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063221-B2 | Aminoquinolones as GSK-3 inhibitors | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2011-11-22 | — | — | US | disclosed |
| EP-2383271-A1 | Aminoquinolones as GSK-3 Inhibitors | Kyorin Pharmaceutical Co., Ltd. (JP) | 2011-11-02 | — | — | EP | disclosed |