Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1345064 | 0.83 | CES2 (0.36) | AKR1C3AKR1C2CES2CES1 | |
| SCHEMBL5535417 | 0.82 | AKR1C3 (0.32) | AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL143557 | 0.82 | MEP1B (0.42) | STING1AKR1C3AKR1C2PPARDPPARA | |
| SCHEMBL10806450 | 0.79 | CES2 (0.33) | AKR1C3AKR1C2CES2CES1 | |
| SCHEMBL9376935 | 0.78 | ALDH1A1 (0.35) | NR1H2NR1H3HSD17B1HSD17B2MEN1 | |
| SCHEMBL607945 | 0.77 | HSD17B10 (0.44) | NR1H2NR1H3HSD17B1HSD17B2MEN1 | |
| SCHEMBL2835358 | 0.77 | HSD17B10 (0.35) | STING1NR1H2NR1H3HSD17B1HSD17B2 | |
| SCHEMBL1344665 | 0.77 | STING1 (0.36) | STING1AKR1C3AKR1C2PPARDPPARA | |
| SCHEMBL10401543 | 0.77 | AKR1C3 (0.35) | AKR1C3AKR1C2PPARDPPARAAKR1C1 | |
| SCHEMBL27927680 | 0.76 | HSD17B10 (0.43) | NR1H2NR1H3HSD17B1HSD17B2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998304-B1 | METHOD FOR PRODUCING (1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-3-QUINOLINE-CARBOXYLIC ACID | DERKACH NATALIIA MYKOLAIVNA (UA) | 2017-08-30 | — | — | EP | disclosed |
| US-9556173-B2 | Method for preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid | DERKACH NATALIIA MYKOLAIVNA (UA) | 2017-01-31 | — | — | US | disclosed |
| US-9556173-B2 | Method for preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid | DERKACH NATALIIA MYKOLAIVNA (UA) | 2017-01-31 | — | — | US | disclosed |
| US-20160159788-A1 | METHOD FOR PREPARATION OF 1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-3-QUINOLINECARBOXYLIC ACID | DERKACH NATALIIA MYKOLAIVNA (UA) | 2016-06-09 | — | — | US | disclosed |
| US-20160159788-A1 | METHOD FOR PREPARATION OF 1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-3-QUINOLINECARBOXYLIC ACID | DERKACH NATALIIA MYKOLAIVNA (UA) | 2016-06-09 | — | — | US | disclosed |
| EP-2998304-A1 | METHOD FOR PRODUCING (1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-3-QUINOLINE-CARBOXYLIC ACID | Derkach, Nataliia Mykolaivna (UA) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998304-A1 | METHOD FOR PRODUCING (1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-3-QUINOLINE-CARBOXYLIC ACID | Derkach, Nataliia Mykolaivna (UA) | 2016-03-23 | — | — | EP | disclosed |
| US-8063221-B2 | Aminoquinolones as GSK-3 inhibitors | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2011-11-22 | — | — | US | disclosed |
| US-5385913-A | 1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents | PFIZER INC. (US) | 1995-01-31 | — | — | US | disclosed |
| EP-0421668-B1 | 1,4-Dihydro-4-oxo-3-quinolone derivatives as selectively toxic mammalian antibacterial agents | PFIZER (US) | 1995-01-04 | — | — | EP | disclosed |
| WO-1991004972-A1 | 1,4-DIHYDRO-4-OXO-3-QUINOLINE DERIVATIVES AS SELECTIVELY TOXIC MAMMALIAN ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 1991-04-18 | — | — | WO | disclosed |
| EP-0421668-A2 | 1,4-Dihydro-4-oxo-3-quinolone derivatives as selectively toxic mammalian antibacterial agents | PFIZER INC. (US) | 1991-04-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159788-A1 | METHOD FOR PREPARATION OF 1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-3-QUINOLINECARBOXYLIC ACID | HPD, OGFOD1, DHODH | STING1 2921/4885AKR1C3 549/4885AKR1C2 1155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.