Symplostatin 1

Symplostatin 1

SCHEMBL1344834

CCC(C)[C@@H](C(=O)N[C@H](C(=O)N(C)[C@@H]([C@@H](C)CC)[C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)c1nccs1)OC)C(C)C)N(C)C

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SSTR2 P30874 2/20 0.40
CYP3A4 P08684 1/20 0.37
PTPRB P23467 1/20 0.34
FOLH1 Q04609 3/20 0.34
TTR P02766 2/20 0.32
CTSD P07339 6/20 0.32
CTSE P14091 6/20 0.32
BACE1 P56817 4/20 0.32
MMP9 P14780 1/20 0.31
REN P00797 2/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Symplostatin 1 SCHEMBL29563593 1.00 SSTR2 (0.40) SSTR2CYP3A4PTPRBFOLH1TTR
Dolastatin-10 SCHEMBL5286 0.98 SSTR2 (0.40) SSTR2CYP3A4PTPRBFOLH1TTR
Dolastatin-10 SCHEMBL16730776 0.98 SSTR2 (0.40) SSTR2CYP3A4PTPRBFOLH1TTR
Dolastatin-10 SCHEMBL12016480 0.98 SSTR2 (0.40) SSTR2CYP3A4PTPRBFOLH1TTR
Dolastatin-10 SCHEMBL6423272 0.98 SSTR2 (0.40) SSTR2CYP3A4PTPRBFOLH1TTR
Dolastatin-10 SCHEMBL23387006 0.98 SSTR2 (0.40) SSTR2CYP3A4PTPRBFOLH1TTR
Dolastatin-10 SCHEMBL13378458 0.98 SSTR2 (0.40) SSTR2CYP3A4PTPRBFOLH1TTR
Dolastatin-10 SCHEMBL22126283 0.98 SSTR2 (0.40) SSTR2CYP3A4PTPRBFOLH1TTR
Dolastatin-10 SCHEMBL22126284 0.98 SSTR2 (0.40) SSTR2CYP3A4PTPRBFOLH1TTR
Dolastatin-10 SCHEMBL13135112 0.98 SSTR2 (0.40) SSTR2CYP3A4PTPRBFOLH1TTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 205 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026105061-A1 ANTIBODY-DRUG CONJUGATES THAT BIND CDCP1 AND USES THEREOF PHEON THERAPEUTICS LTD (GB) 2026-05-21 WO claimed
US-10220090-B2 BCMA Antigen binding proteins AMGEN INC. (US) 2019-03-05 US claimed
US-20190008974-A9 BCMA ANTIGEN BINDING PROTEINS AMGEN INC. (US) 2019-01-10 US claimed
US-20170165373-A1 BCMA ANTIGEN BINDING PROTEINS AMGEN INC. (US) 2017-06-15 US claimed
US-9243058-B2 BCMA antigen binding proteins AMGEN, INC. (US) 2016-01-26 US claimed
US-20150344583-A1 BCMA ANTIGEN BINDING PROTEINS AMGEN INC. 2015-12-03 US claimed
EP-2928922-A2 BCMA ANTIGEN BINDING PROTEINS Amgen Inc. (US) 2015-10-14 EP claimed
US-20140161828-A1 BCMA ANTIGEN BINDING PROTEINS AMGEN INC. (US) 2014-06-12 US claimed
WO-2014089335-A2 BCMA ANTIGEN BINDING PROTEINS AMGEN INC. (US) 2014-06-12 WO claimed
WO-2026105061-A1 ANTIBODY-DRUG CONJUGATES THAT BIND CDCP1 AND USES THEREOF PHEON THERAPEUTICS LTD (GB) 2026-05-21 WO disclosed
US-12583932-B2 CD38 and ICAM1 antibodies and uses thereof VIRTUOSO BINCO, INC. (US) 2026-03-24 US disclosed
EP-4684799-A2 ANTIBODIES THAT DISRUPT THE INTERACTION OF GAL3 AND INSULIN RECEPTOR OR INTEGRINS AND METHODS OF USE THEREOF TrueBinding, Inc. (US) 2026-01-28 EP disclosed
EP-4673181-A1 USE OF ANTI-CEACAM5 IMMUNOCONJUGATES FOR TREATING NEUROENDOCRINE CANCERS EXPRESSING CEACAM5 Sanofi (FR) 2026-01-07 EP disclosed
US-12497458-B2 Anti-GAL3 antibodies and uses thereof TRUEBINDING, INC. (US) 2025-12-16 US disclosed
US-20050053608-A1 Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof AMGEN FREMONT INC. 2005-03-10 US disclosed
WO-2005012479-A2 ANTIBODIES DIRECTED TO THE DELETION MUTANTS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREOF ABGENIX, INC (US) 2005-02-10 WO disclosed
WO-2005010151-A2 ANTIBODIES DIRECTED TO THE DELETION MUTANTS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREOF ABGENIX, INC (US) 2005-02-03 WO disclosed
US-6638528-B1 Pressure-sensitive adhesive matrix comprising blend of polyacrylate, polysiloxane, polyisobutylene, polyisoprene, polyamide or polystyrene; and insoluble, non-adhesive ethyl cellulose; polyvinylpyrrolidone crystallization inhibitor NOVEN PHARMACEUTICALS, INC. 2003-10-28 US disclosed
WO-2003033523-A2 CYTOTOXIC COMPOUNDS INSTITUTO BIOMAR S.A. (ES) 2003-04-24 WO disclosed
US-20020004065-A1 Compositions and methods to effect the release profile in the transdermal administration of active agents KANIOS DAVID (US) 2002-01-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170165373-A1 BCMA ANTIGEN BINDING PROTEINS CD79B, BCR, BCDIN3D SSTR2 4170/4885CYP3A4 4671/4885PTPRB 68/4885
US-20150344583-A1 BCMA ANTIGEN BINDING PROTEINS CD79B, BCR, BCAP31 SSTR2 4231/4885CYP3A4 4741/4885PTPRB 79/4885
US-20190008974-A9 BCMA ANTIGEN BINDING PROTEINS CD79B, BCR, BCDIN3D SSTR2 4170/4885CYP3A4 4671/4885PTPRB 68/4885
US-20140161828-A1 BCMA ANTIGEN BINDING PROTEINS CD79B, BCR, BCDIN3D SSTR2 4170/4885CYP3A4 4671/4885PTPRB 68/4885
US-12583932-B2 CD38 and ICAM1 antibodies and uses thereof FCGR2A, FCGR3B, FCGR1A SSTR2 1696/4885CYP3A4 4262/4885PTPRB 521/4885
US-10220090-B2 BCMA Antigen binding proteins CD79B, BCR, BCDIN3D SSTR2 4170/4885CYP3A4 4671/4885PTPRB 68/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.