Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 5/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | DDIT3 | P35638 | 1/20 | 0.34 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CCR7 | P32248 | 1/20 | 0.32 |
| ▸ | CCR6 | P51684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1581747 | 0.85 | GCK (0.60) | GCKCNR2KMT2AMEN1HSD11B1 | |
| SCHEMBL2654841 | 0.85 | GCK (0.60) | GCKCNR2KMT2AMEN1HSD11B1 | |
| SCHEMBL1582235 | 0.84 | GCK (0.58) | GCKCNR2KMT2AMEN1HSD11B1 | |
| SCHEMBL1346564 | 0.82 | GCK (0.43) | GCKNAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1582297 | 0.82 | GCK (0.47) | GCKCNR2KMT2ACYP2C9HSD11B1 | |
| SCHEMBL1581983 | 0.82 | GCK (0.49) | GCKKMT2AMEN1CYP2C9ALDH1A1 | |
| SCHEMBL1582299 | 0.80 | GCK (0.45) | GCKKMT2AALDH1A1 | |
| SCHEMBL1581700 | 0.79 | HSD11B1 (0.42) | GCKHSD11B1SMN1; SMN2 | |
| SCHEMBL1581954 | 0.79 | GCK (0.40) | GCKKMT2AMEN1HSD11B1ALDH1A1 | |
| SCHEMBL1581770 | 0.79 | GCK (0.40) | GCKCYP2C9HSD11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379517-B1 | Arylcyclopropylacetamide derivatives useful as glucokinase activators | LILLY CO ELI (US) | 2013-08-28 | — | — | EP | disclosed |
| EP-2379517-B1 | Arylcyclopropylacetamide derivatives useful as glucokinase activators | LILLY CO ELI (US) | 2013-08-28 | — | — | EP | disclosed |
| US-8063079-B2 | Cyclopropyl compounds | ELI LILLY AND COMPANY (US) | 2011-11-22 | — | — | US | disclosed |
| US-8063079-B2 | Cyclopropyl compounds | ELI LILLY AND COMPANY (US) | 2011-11-22 | — | — | US | disclosed |
| US-8063079-B2 | Cyclopropyl compounds | ELI LILLY AND COMPANY (US) | 2011-11-22 | — | — | US | disclosed |
| US-20100160395-A1 | CYCLOPROPYL COMPOUNDS | ELI LILLY AND COMPANY | 2010-06-24 | — | — | US | disclosed |
| US-20100160395-A1 | CYCLOPROPYL COMPOUNDS | ELI LILLY AND COMPANY | 2010-06-24 | — | — | US | disclosed |
| US-20100160395-A1 | CYCLOPROPYL COMPOUNDS | ELI LILLY AND COMPANY | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160395-A1 | CYCLOPROPYL COMPOUNDS | IAPP, GPR119, SLC5A2 | GCK 57/4885NAMPT 707/4885CNR2 556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.