Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 13/20 | 0.36 |
| ▸ | MAOA | P21397 | 11/20 | 0.36 |
| ▸ | MAOB | P27338 | 11/20 | 0.36 |
| ▸ | HTR2B | P41595 | 11/20 | 0.36 |
| ▸ | HTR5A | P47898 | 4/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29946198 | 0.71 | MAOA (0.33) | HTR2CMAOAMAOBHTR2BHTR5A | |
| SCHEMBL23537533 | 0.64 | CYP1A2 (0.41) | MAOAMAOBCA1CA2CA4 | |
| SCHEMBL12709073 | 0.61 | — | — | |
| SCHEMBL24150788 | 0.59 | METAP1 (0.33) | MAOAMAOBGAAMAPT | |
| SCHEMBL28662585 | 0.59 | MAOA (0.42) | MAOAMAOBCA1CA2CA4 | |
| SCHEMBL340066 | 0.58 | TRPA1 (0.68) | MAOAMAOBHTR2BCA1CA2 | |
| SCHEMBL29819939 | 0.58 | TRPA1 (0.68) | MAOAMAOBHTR2BCA1CA2 | |
| SCHEMBL9426830 | 0.57 | TRPA1 (0.40) | HTR2BALOX5MEN1LMNATP53 | |
| SCHEMBL23317928 | 0.57 | MAOA (0.48) | HTR2CMAOAMAOBHTR2BHTR5A | |
| SCHEMBL1134706 | 0.57 | MAOA (0.55) | MAOAMAOBCA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687643-B2 | Process for preparing 3,3-dimethylindolines | AMGEN INC. (US) | 2010-03-30 | — | — | US | disclosed |